methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

Base Information

• Chemical Name: methyl 4-amino-5-(ethylthio)-2-methoxybenzoate
• CAS No.: 1119455-01-4
• Molecular Formula: C₁₁H₁₅NO₃S
• Molecular Weight: 241.311
• Mol file: 1119455-01-4.mol

Synonyms:methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

Chemical Property of methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

There total 3 articles about methyl 4-amino-5-(ethylthio)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl sulfate (64-67-5) + methyl 4-amino-2-methoxy-5-thiocyanatobenzoate (59168-56-8) → methyl 4-amino-5-(ethylthio)-2-methoxybenzoate (1119455-01-4)

Guidance literature:

With sodium sulfide; In water; acetone; at 5 - 15 ℃; Industry scale;

Reference yield:

Methyl 4-amino-2-methoxybenzoate (27492-84-8) → methyl 4-amino-5-(ethylthio)-2-methoxybenzoate (1119455-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / methanol / 5 - 15 °C / Industry scale

2: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale

With sodium sulfide; bromine; In methanol; water; acetone;

Reference yield:

4-Aminosalicylic acid (65-49-6) → methyl 4-amino-5-(ethylthio)-2-methoxybenzoate (1119455-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide; tetrabutylammomium bromide / acetone / 1 h / 25 - 35 °C / Industry scale

2: bromine / methanol / 5 - 15 °C / Industry scale

3: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale

With sodium sulfide; tetrabutylammomium bromide; bromine; potassium hydroxide; In methanol; water; acetone;

upstream raw materials:

Methyl 4-amino-2-methoxybenzoate

diethyl sulfate

methyl 4-amino-2-methoxy-5-thiocyanatobenzoate

4-Aminosalicylic acid

Downstream raw materials:

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

amisulpride

Refernces