6-Fluoro-benzooxazole-2-thiol

Base Information

• Chemical Name: 6-Fluoro-benzooxazole-2-thiol
• CAS No.: 145096-57-7
• Molecular Formula: C7H4FNOS
• Molecular Weight: 169.179
• Hs Code.: 2934999090
• Mol file: 145096-57-7.mol

Synonyms:6-Fluoro-benzooxazole-2-thiol

Chemical Property of 6-Fluoro-benzooxazole-2-thiol

Chemical Property:

• PSA: 64.83000
• LogP: 2.25560

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Fluoro-1,3-benzoxazole-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-benzooxazole-2-thiol

There total 6 articles about 6-Fluoro-benzooxazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium ethyl xanthogenate (140-89-6) + 2-amino-5-fluorophenol (53981-24-1) → 6-fluoro-1,3-benzoxazole-2-thiol (145096-57-7)

Guidance literature:

potassium ethyl xanthogenate; 2-amino-5-fluorophenol; In ethanol; Reflux;

With hydrogenchloride; In water;

Reference yield: 89.0%

→ 6-fluoro-1,3-benzoxazole-2-thiol (145096-57-7)

Guidance literature:

In ethanol; for 16h; Reflux;

Reference yield: 86.0%

carbon disulfide (75-15-0,12122-00-8) + 2-amino-5-fluorophenol (53981-24-1) → 6-fluoro-1,3-benzoxazole-2-thiol (145096-57-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 72h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2014.05.088

upstream raw materials:

potassium ethyl xanthogenate

2-amino-5-fluorophenol

5-fluoro-2-nitrophenol

carbon disulfide

Downstream raw materials:

C₁₇H₁₆Cl₂FN₃O

2-chloro-6-fluoro-1,3-benzoxazole

6-fluoro-2-piperazin-1-yl-benzooxazole

C₁₈H₁₇FN₄O₂

Refernces

• 1、 -. "SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 131. . Retrieved 2019/03/17.
• 2、 Rynearson, Kevin D.,Charrette, Brian,Gabriel, Christopher,Moreno, Jesus,Boerneke, Mark A.,Dibrov, Sergey M.,Hermann, Thomas. "2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site". . p. 3521 - 3525. Retrieved 2014/07/22.