Technology Process of Ralimetinib
There total 11 articles about Ralimetinib which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Triethoxysilane; zinc diacetate;
In
tetrahydrofuran; dichloromethane;
at 60 ℃;
for 20h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.orglett.5b01307
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ozone / ethyl acetate / 937.59 Torr / Flow reactor
2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0.5 h / 25 °C
2.2: 12 h / 60 °C
3.1: dimethylsulfide borane complex / 15 h / 20 °C
With
dimethylsulfide borane complex; tetra(n-butyl)ammonium hydrogensulfate; ozone; sodium hydroxide;
In
ethyl acetate; acetonitrile;
1.1: |Griesbaum Coozonolysis;
DOI:10.1021/acs.orglett.5b01307
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; palladium on carbon / ethanol; water / 100 °C / 3750.38 Torr / Flow reactor
2.1: dmap; triethylamine / dichloromethane / 20 °C / Flow reactor
3.1: ozone / ethyl acetate / 937.59 Torr / Flow reactor
4.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0.5 h / 25 °C
4.2: 12 h / 60 °C
5.1: zinc diacetate; Triethoxysilane / tetrahydrofuran; dichloromethane / 20 h / 60 °C / Inert atmosphere; Schlenk technique
With
dmap; Triethoxysilane; palladium on carbon; zinc diacetate; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; ozone; triethylamine; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
3.1: |Griesbaum Coozonolysis;
DOI:10.1021/acs.orglett.5b01307
