1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone

Base Information

• Chemical Name: 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone
• CAS No.: 27822-68-0
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2933990090
• Mol file: 27822-68-0.mol

Synonyms:1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone;1-[2-(hydroxyMethyl)-1-pyrrolidinyl]-Ethanone

Chemical Property of 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone

Chemical Property:

• PSA: 40.54000
• LogP: -0.07250

Purity/Quality:

≥95% ^*data from raw suppliers

1-(2-(Hydroxymethyl)pyrrolidin-1-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone

There total 3 articles about 1-(2-HydroxyMethyl-pyrrolidin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → N-acetylprolinol (27822-68-0,123958-87-2)

Guidance literature:

In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo00250a010

Reference yield: 94.0%

acetic anhydride (108-24-7) + 2-hydroxymethylpyrrolidine (498-63-5) → N-acetylprolinol (27822-68-0,123958-87-2)

Guidance literature:

acetic anhydride; 2-hydroxymethylpyrrolidine; In ethyl acetate; at 20 ℃; for 8h; Inert atmosphere;

With potassium carbonate; In ethyl acetate; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1080/00397910902978007

Reference yield:

→ N-acetylprolinol (27822-68-0,123958-87-2)

Guidance literature:

d, Pyrrolidin, Ac2O, in Acn. + wss. NaOH;

DOI:10.1246/bcsj.42.3524

upstream raw materials:

acetic anhydride

2-hydroxymethylpyrrolidine

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

(R)-N-((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide

(R)-N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide

1-ethyl-2-pyrrolidinemethanamine

1-acetyl-2-formylpyrrolidine

Refernces

• 1、 Bishop,Mathis,Gerdes,Whitney,Eaton,Mailman. "Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: High-affinity ligands for CNS dopamine D2 receptors". . p. 1612 - 1624. Retrieved 2007/10/02.