3,4-Dihydro Agomelatine

Base Information

• Chemical Name: 3,4-Dihydro Agomelatine
• CAS No.: 1352139-51-5
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.321
• Mol file: 1352139-51-5.mol

Synonyms:3,4-Dihydro Agomelatine

Chemical Property of 3,4-Dihydro Agomelatine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro Agomelatine

There total 1 articles about 3,4-Dihydro Agomelatine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(7-methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile (861960-34-1) → N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide (1352139-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; ammonia / Raney nickel / ethanol; water / 3 h / 40 °C / Autoclave vessel

2: ethanol / 0.5 h / 0 - 5 °C

With ammonia; hydrogen; Raney nickel; In ethanol; water;

Reference yield: 91.8%

N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide (1352139-51-5) → agomelatine (138112-76-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃;

Reference yield:

N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide (1352139-51-5) → Agomelatine hydrochloride (1176316-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 - 30 °C

2: hydrogenchloride / ethyl acetate / 1.5 h / 0 - 5 °C / pH 2

With hydrogenchloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; ethyl acetate;

upstream raw materials:

2-(7-methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile

Downstream raw materials:

agomelatine

Agomelatine hydrochloride

Refernces