3-Bromo-N-Methoxy-N-Methylpicolinamide

Base Information

• Chemical Name: 3-Bromo-N-Methoxy-N-Methylpicolinamide
• CAS No.: 867353-49-9
• Molecular Formula: C8H9BrN2O2
• Molecular Weight: 245.076
• Mol file: 867353-49-9.mol

Synonyms:3-Bromo-N-Methoxy-N-Methylpicolinamide

Chemical Property of 3-Bromo-N-Methoxy-N-Methylpicolinamide

Chemical Property:

• PSA: 42.43000
• LogP: 1.47750

Purity/Quality:

3-bromo-N-methoxy-N-methylpicolinamide 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-N-Methoxy-N-Methylpicolinamide

There total 2 articles about 3-Bromo-N-Methoxy-N-Methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 3-bromopicolinic acid (30683-23-9) → 3-bromo-N-methoxy-N-methylpyridine-2-carboxamide (867353-49-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

C6H4BrNO2*ClH + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 3-bromo-N-methoxy-N-methylpyridine-2-carboxamide (867353-49-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 22 ℃; for 6h;

DOI:10.1021/ja802935w

Reference yield: 85.0%

3-bromo-N-methoxy-N-methylpyridine-2-carboxamide (867353-49-9) + 2-Methoxyphenylboronic acid (5720-06-9) → C15H16N2O3

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); caesium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

3-bromopicolinic acid

Downstream raw materials:

3-bromopicolinaldehyde

1-(3-bromopyridin-2-yl)-3-phenylprop-2-yn-1-one

Refernces

• 1、 -. "PHARMACEUTICALS COMPRISING BIARYL DERIVATIVES OR SALTS THEREOF". Paragraph 0911; 0912; 0913. . Retrieved 2018/10/24.
• 2、 -. "INHIBITORS OF AKT ACTIVITY". Page/Page column 53-54. . Retrieved 2010/02/14.