(R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl

Base Information

• Chemical Name: (R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl
• CAS No.: 1167414-89-2
• Molecular Formula: C9H14ClNO
• Molecular Weight: 187.669
• Mol file: 1167414-89-2.mol

Synonyms:(R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl;(R)-1-(3-Methoxyphenyl)ethanaMine hydrochloride

Chemical Property of (R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl

Chemical Property:

• PSA: 35.25000
• LogP: 3.21720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-(3-Methoxyphenyl)ethanaminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl

There total 6 articles about (R)-1-(3-METHOXYPHENYL)ETHYLAMINE-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(R)-[1-(3-methoxyphenyl)ethyl]carbamic acid tert-butyl ester (871728-33-5) → (R)-1-(3-methoxyphenyl)ethanamine hydrochloride salt (1167414-89-2,854184-18-2)

Guidance literature:

With hydrogenchloride; water; In methanol; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1080/00397911.2010.527425

Reference yield:

3-((R)-1-((R)-1-phenylethylamino)ethyl)phenol (1372628-56-2) → (R)-1-(3-methoxyphenyl)ethanamine hydrochloride salt (1167414-89-2,854184-18-2)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid / 48 h / 20 °C / 3102.97 Torr / Inert atmosphere

2: triethylamine / methanol / 6 h / 0 °C / Inert atmosphere

3: potassium carbonate / acetone / 0 °C / Inert atmosphere; Reflux

4: hydrogenchloride; water / methanol / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; triethylamine; In methanol; acetic acid; acetone;

DOI:10.1080/00397911.2010.527425

Reference yield:

3-Hydroxyacetophenone (121-71-1) → (R)-1-(3-methoxyphenyl)ethanamine hydrochloride salt (1167414-89-2,854184-18-2)

Guidance literature:

Multi-step reaction with 6 steps

1: titanium(IV) isopropylate / ethyl acetate / 3 h / Inert atmosphere

2: sodium tetrahydroborate / ethanol; ethyl acetate / 3 h / 0 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / acetic acid / 48 h / 20 °C / 3102.97 Torr / Inert atmosphere

4: triethylamine / methanol / 6 h / 0 °C / Inert atmosphere

5: potassium carbonate / acetone / 0 °C / Inert atmosphere; Reflux

6: hydrogenchloride; water / methanol / 12 h / 20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; triethylamine; In methanol; ethanol; acetic acid; ethyl acetate; acetone;

DOI:10.1080/00397911.2010.527425

upstream raw materials:

3-((R)-1-((R)-1-phenylethylamino)ethyl)phenol

3-Hydroxyacetophenone

(R)-1-(3-hydroxyphenyl)ethylamine

(R)-[1-(3-methoxyphenyl)ethyl]carbamic acid tert-butyl ester

Downstream raw materials:

tecalcet

(R)-3-(2-chlorophenyl)-N-(1-(3'-methoxyphenyl)ethyl)propanamide

3-(2-chlorophenyl)-N-[(R)-1-(3-methoxyphenyl)ethyl]-2-propenamide

Refernces