3-bromo-4-hydroxybenzeneethanol

Base Information

• Chemical Name: 3-bromo-4-hydroxybenzeneethanol
• CAS No.: 196081-78-4
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.062
• Mol file: 196081-78-4.mol

Synonyms:3-bromo-4-hydroxybenzeneethanol

Chemical Property of 3-bromo-4-hydroxybenzeneethanol

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-hydroxybenzeneethanol

There total 1 articles about 3-bromo-4-hydroxybenzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-hydroxyphenethyl alcohol (501-94-0) → 3-bromo-4-hydroxyphenylethyl alcohol (196081-78-4)

Guidance literature:

With oxone; sodium bromide; In water; acetone; at 20 ℃;

DOI:10.1080/00397911.2015.1133828

Reference yield: 100.0%

2-Methoxyethoxymethyl chloride (3970-21-6) + 3-bromo-4-hydroxyphenylethyl alcohol (196081-78-4) → 2-bromo-1-(2-methoxyethoxymethoxy)-4-[2-(2-methoxyethoxymethoxy)ethyl]benzene (731015-40-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield: 97.3%

sodium methylate (124-41-4) + 3-bromo-4-hydroxyphenylethyl alcohol (196081-78-4) → homovanillyl alcohol (2380-78-1)

Guidance literature:

With copper(I) bromide; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

DOI:10.1080/00397910701575509

upstream raw materials:

p-hydroxyphenethyl alcohol

Downstream raw materials:

homovanillyl alcohol

1-bromo-5-(2-hydroxyethyl)-2-methoxybenzene

5-(2-azidoethyl)-1-bromo-2-methoxybenzene

methanesulfonic acid 2-(3-bromo-4-methoxy-phenyl)-ethyl ester

Refernces

• 1、 -. "Synthesis method for hydroxytyrosol". Paragraph 0052-0057; 0063-0065; 0068-0070; 0073-0076; 0080. . Retrieved 2021/03/11.
• 2、 Dong, Hong-Bo,Meng, Jian,Yao, Zhong-Quan,Luo, Hong-Bing,Zhang, Jing-Xia,Du, Wei-Hong,Tang, Ke-Hui,Cao, Sheng-Hua. "Total synthesis of three natural phenethyl glycosides". . p. 284 - 293. Retrieved 2020/03/03.