Dimethyl piperidine-2,5-dicarboxylate

Base Information

• Chemical Name: Dimethyl piperidine-2,5-dicarboxylate
• CAS No.: 2207-52-5
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.222
• Hs Code.: 2933399090
• European Community (EC) Number: 843-843-7
• DSSTox Substance ID: DTXSID40540031
• Nikkaji Number: J803.115K
• Mol file: 2207-52-5.mol

Synonyms:DIMETHYL PIPERIDINE-2,5-DICARBOXYLATE;2207-52-5;2,5-dimethyl piperidine-2,5-dicarboxylate;2,5-Piperidinedicarboxylic acid, 2,5-diMethyl ester;Dimethylpiperidine-2,5-dicarboxylate;SCHEMBL69462;DTXSID40540031;CAA20752;CS-D1077;AKOS016013638;dimethyl piperidine-2, 5-dicarboxylate;EN300-312248;F8889-9288

Chemical Property of Dimethyl piperidine-2,5-dicarboxylate

Chemical Property:

• Boiling Point: 104-106 °C(Press: 0.4 Torr)
• PKA: 7.10±0.10(Predicted)
• PSA: 64.63000
• Density: 1.132±0.06 g/cm3(Predicted)
• LogP: 0.02940
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 201.10010796
• Heavy Atom Count: 14
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

2,5-dimethylpiperidine-2,5-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CCC(NC1)C(=O)OC

Technology Process of Dimethyl piperidine-2,5-dicarboxylate

There total 6 articles about Dimethyl piperidine-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl 2,5-pyridine dicarboxylate (881-86-7) → piperidine-2,5-dicarboxylic acid dimethyl ester (2207-52-5,98935-66-1,98935-68-3,150213-71-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid;

DOI:10.1016/0957-4166(95)00003-8

Reference yield: 90.0%

dimethyl 2,5-pyridine dicarboxylate (881-86-7) → cis-2,5-Piperidinedicarboxylic acid methyl ester (2207-52-5,98935-66-1,98935-68-3,150213-71-1)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; under 2585.7 Torr;

Reference yield: 80.0%

methanol (67-56-1) + (+/-)-cis-2,5-piperidinedicarboxylic acid (84229-41-4) → cis-2,5-Piperidinedicarboxylic acid methyl ester (2207-52-5,98935-66-1,98935-68-3,150213-71-1)

Guidance literature:

With sulfuric acid; for 4h; Heating;

DOI:10.1007/BF00506672

upstream raw materials:

dimethyl 2,5-pyridine dicarboxylate

methanol

trans-2,5-piperidinedicarboxylic acid

(+/-)-cis-2,5-piperidinedicarboxylic acid

Downstream raw materials:

5-(methoxycarbonyl)piperidine-2-carboxylic acid

trans-5-(methoxycarbonyl)piperidine-2-carboxylic acid

cis-5-(methoxycarbonyl)piperidine-2-carboxylic acid

dimethyl trans-1-(2-(phthalimido)ethyl)piperidine-2,5-dicarboxylate

Refernces

• 1、 Urban, Frank J.,Breitenbach, Ralph,Murtiashaw, Charles W.,Vanderplas, Brian C.. "Synthesis of an Optically Active Octahydro-2H-pyridopyrazine Based CNS Agent". . p. 321 - 324. Retrieved 2007/10/02.
• 2、 Mastafanova, L. I.,Turchin, K. F.,Evstratova, M. I.,Sheinker, Yu. N.,Yakhontov, L. N.. "SYNTHESIS AND CONFIGURATION OF DIASTEREOMERIC 2,4-, 2,5-, AND 2,6-PIPERIDINEDICARBOXYLIC ACIDS AND THEIR DIMETHYL ESTERS". . p. 305 - 309. Retrieved 2007/10/02.