4-Methylumbelliferyl Methanethiosulfonate

Base Information

• Chemical Name: 4-Methylumbelliferyl Methanethiosulfonate
• CAS No.: 1076198-63-4
• Molecular Formula: C₁₁H₁₀O₄S₂
• Molecular Weight: 270.33
• Mol file: 1076198-63-4.mol

Synonyms:4-Methylumbelliferyl Methanethiosulfonate;Methanesulfonothioic Acid S-(4-Methyl-2-oxo-2H-1-benzopyran-7-yl) Ester

Chemical Property of 4-Methylumbelliferyl Methanethiosulfonate

Chemical Property:

• Melting Point: 174-176°C
• PSA: 98.03000
• LogP: 3.23390
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

98% ^*data from raw suppliers

4-Methylumbelliferyl Methanethiosulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluorecent thiol derivative Fluorecent thiol derivative.

Technology Process of 4-Methylumbelliferyl Methanethiosulfonate

There total 4 articles about 4-Methylumbelliferyl Methanethiosulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium methansulfinate (20277-69-4) + 7-mercapto-4-methyl-2H-chromen-2-one (137215-27-1) → 4-methyl-7-methanesulfonothioatecoumarin (1076198-63-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1039/c5cc05390k

Reference yield:

7-[(N,N-dimethyl)thiocarbamoyloxy]-4-methyl-2H-chromen-2-one (173599-90-1) → 4-methyl-7-methanesulfonothioatecoumarin (1076198-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 210 °C / Inert atmosphere

2: sodium methylate / methanol / 8 h / Inert atmosphere

3: N-Bromosuccinimide / acetonitrile / 8 h / 20 °C

With N-Bromosuccinimide; sodium methylate; In methanol; acetonitrile;

DOI:10.1039/c5cc05390k

Reference yield:

7-[(N,N-dimethyl)carbamoylthio]-4-methyl-2H-chromen-2-one (173599-91-2) → 4-methyl-7-methanesulfonothioatecoumarin (1076198-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / methanol / 8 h / Inert atmosphere

2: N-Bromosuccinimide / acetonitrile / 8 h / 20 °C

With N-Bromosuccinimide; sodium methylate; In methanol; acetonitrile;

DOI:10.1039/c5cc05390k

upstream raw materials:

7-[(N,N-dimethyl)thiocarbamoyloxy]-4-methyl-2H-chromen-2-one

7-[(N,N-dimethyl)carbamoylthio]-4-methyl-2H-chromen-2-one

sodium methansulfinate

7-mercapto-4-methyl-2H-chromen-2-one

Refernces