CIS-2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: CIS-2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID
• CAS No.: 5691-20-3
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 29224985
• Mol file: 5691-20-3.mol

Synonyms:C-ddG;Carbocyclic-2',3'-dideoxyguanosine;2-aminocyclohexanecarboxylic acid;

Chemical Property of CIS-2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Appearance/Colour: almost white to light beige crystalline powder
• Vapor Pressure: 0.00103mmHg at 25°C
• Melting Point: ~240 °C (dec.)
• Refractive Index: 1.503
• Boiling Point: 280 °C at 760 mmHg
• Flash Point: 123.1 °C
• PSA: 63.32000
• Density: 1.133g/cm³
• LogP: 1.28880

Purity/Quality:

99%, ^*data from raw suppliers

cis-2-Aminocyclohexanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID

There total 68 articles about CIS-2-AMINO-1-CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-2-(dibenzylamino)cyclohexane-1-carboxylic acid → (1R,2R)-2-aminocyclohexanecarboxylic Acid (5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 60h; under 1034.32 Torr;

DOI:10.1016/j.tetlet.2014.12.101

Reference yield: 99.0%

7-azabicyclo<4.2.0>octan-8-one (34102-49-3) → (1RS,2SR)-2-aminocyclohexanecarboxylic acid (5691-20-3)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 0.5h;

DOI:10.1055/s-2004-831224

Reference yield: 92.0%

(1S,2S)-1-cyano-2-[N-(4-nitrobenzoyl)amino]cyclohexane (864445-67-0) → rac-trans-2-aminocyclohexanecarboxylic acid (5691-19-0,5691-20-3,24716-93-6,26685-83-6,45743-49-5,57090-28-5,75081-40-2)

Guidance literature:

With hydrogenchloride; at 90 ℃; for 120h;

DOI:10.1021/ja053486y DOI:10.1016/j.tet.2007.02.081

upstream raw materials:

ethyl cis-2-amino-1-cyclohexanecarboxylate

2-benzenesulfonyloxy-(3ar,7ac)-hexahydro-isoindole-1,3-dione

cis-hexahydrophthalimide

phthalimide

Downstream raw materials:

(+/-)-cis-2-formylamino-cyclohexanecarboxylic acid

(+/-)-cis-2-(toluene-4-sulfonylamino)-cyclohexane carboxylic acid

(1S,2S)-2-(benzothiazol-2-ylamino)cyclohexylmethanol

(1S,2S)-2-amino-cyclohexylmethanol

Refernces

• 1、 Joannesse, Caroline,Johnston, Craig P.,Morrill, Louis C.,Woods, Philip A.,Kieffer, Madeleine,Nigst, Tobias A.,Mayr, Herbert,Lebl, Tomas,Philp, Douglas,Bragg, Ryan A.,Smith, Andrew D.. "Isothiourea-mediated asymmetric O- to C-carboxyl transfer of oxazolyl carbonates: Structure-selectivity profiles and mechanistic studies". supporting information; experimental part. p. 2398 - 2408. Retrieved 2012/03/27.
• 2、 Dutot, Laurence,Gaucher, Anne,Elkassimi, Khadidja,Drapeau, Jeremy,Wakselman, Michel,Mazaleyrat, Jean-Paul,Peggion, Cristina,Formaggio, Fernando,Toniolo, Claudio. "Synthesis and characterisation of helical β-peptide architectures that contain (S)-β3-HDOPA(crown ether) derivatives". supporting information; scheme or table. p. 3154 - 3163. Retrieved 2009/04/11.