Propargyl chloride

Base Information

• Chemical Name: Propargyl chloride
• CAS No.: 624-65-7
• Molecular Formula: C3H3Cl
• Molecular Weight: 74.5098
• Hs Code.: 2942000000
• European Community (EC) Number: 210-856-9
• NSC Number: 66411
• UNII: 3M62YFL252
• DSSTox Substance ID: DTXSID4060789
• Nikkaji Number: J22.069H
• Wikipedia: Propargyl_chloride
• Wikidata: Q420202
• Mol file: 624-65-7.mol

Synonyms:propargyl chloride

Chemical Property of Propargyl chloride

Chemical Property:

• Appearance/Colour: colorless flammable liquid
• Vapor Pressure: 235mmHg at 25°C
• Melting Point: <-50 °C
• Refractive Index: 1.4350
• Boiling Point: 57 °C at 760 mmHg
• Flash Point: 18.9 °C
• PSA: 0.00000
• Density: 1.017 g/cm³
• LogP: 0.85840
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 73.9923278
• Heavy Atom Count: 4
• Complexity: 38.5

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): F, T, C
• Hazard Codes: F:Flammable;;
• Statements: R11:; R23/24/25:; R34:
• Safety Statements: S16:; S26:; S27:; S36/37/39:; S45:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Halogenated Aliphatics, Unsaturated
• Canonical SMILES: C#CCCl

Technology Process of Propargyl chloride

There total 12 articles about Propargyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.98%

1,1-dimethylprop-3-ynylamine (2978-58-7) → 2-propynyl chloride (624-65-7)

Guidance literature:

With 3,5-dichlorobenzoyl chloride; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Time; Reagent/catalyst;

Reference yield: 94.0%

propargyl alcohol (107-19-7) → 2-propynyl chloride (624-65-7)

Guidance literature:

With thionyl chloride; tetramethylurea; In toluene; at 40 ℃; for 3.16h;

Reference yield: 32.0%

N,N-Dichlorobenzenesulfonamide (473-29-0) + propargyl alcohol (107-19-7) → benzenesulfonamide (98-10-2) + N-chlorobenzenesulfonamide (80-16-0) + 2-propynyl chloride (624-65-7) + 3-hydroxy-2,2-dichloro-1,1-di(N-benzenesulfonamide)propane

Guidance literature:

In tetrachloromethane; at 30 - 35 ℃; for 6h; Irradiation;

upstream raw materials:

phosgene

propargyl alcohol

3-bromo-2-chloroprop-1-ene

2-bromo-3-chloro-propene

Downstream raw materials:

4-(but-3-yn-1-yl)pyridine

3-phenyl-5-chloromethyl-1,2,4-oxadiazole

5-prop-2-ynylmercapto-3H-[1,3,4]thiadiazole-2-thione

N-(1-Propyl)propargylamine

Refernces

• 1、 Martynov,Makhaeva,Larina,Amosova. "Reaction of tellurium tetrachloride with propargyl halides". . p. 1249 - 1252. Retrieved 2015.
• 2、 -. "Novel synthesis method of propyzamide". Paragraph 0020-0021; 0022-0023; 0024-0025; 0026-0031. . Retrieved 2021/04/17.