(3-Chloropyrazin-2-yl)MethanaMine hydrochloride

Base Information

• Chemical Name: (3-Chloropyrazin-2-yl)MethanaMine hydrochloride
• CAS No.: 939412-86-9
• Molecular Formula: C5H7Cl2N3
• Molecular Weight: 180.037
• Hs Code.: 2933990090
• Mol file: 939412-86-9.mol

Synonyms:3-Chloro-2-pyrazinemethanamine hydrochloride;2-Pyrazinemethanamine, 3-chloro-, hydrochloride (1:1)

Chemical Property of (3-Chloropyrazin-2-yl)MethanaMine hydrochloride

Chemical Property:

• PSA: 51.80000
• LogP: 2.09100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3-Chloropyrazin-2-yl)methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Chloropyrazin-2-yl)MethanaMine hydrochloride

There total 4 articles about (3-Chloropyrazin-2-yl)MethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-3-cyanopyrazine (55557-52-3) → C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt (939412-86-9,867165-53-5)

Guidance literature:

With hydrogen; acetic acid; at 20 ℃; for 36h;

Reference yield:

2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione (867165-55-7) → C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt (939412-86-9,867165-53-5)

Guidance literature:

2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione; With hydrazine; In methanol; at 60 ℃; for 1h;

With hydrogenchloride; In toluene; Product distribution / selectivity;

Reference yield:

1-(3-chloro-pyrazin-2-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane; chloride (939412-88-1) → C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt (939412-86-9,867165-53-5)

Guidance literature:

1-(3-chloro-pyrazin-2-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane; chloride; With hydrogenchloride; water; In methanol; for 1h; Heating / reflux;

With sodium carbonate; In methanol; water; toluene;

With hydrogenchloride; In isopropyl alcohol; for 0.5h; Product distribution / selectivity;

upstream raw materials:

2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione

1-(3-chloro-pyrazin-2-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane; chloride

N-(3-chloro-pyrazin-2-ylmethyl)-N-formyl-formamide

2-chloro-3-cyanopyrazine

Downstream raw materials:

N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide

benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate

Refernces

• 1、 -. "IMIDAZOPYRIDINAMINE PHENYL DERIVATIVE AND USE THEREOF". Paragraph 0038. . Retrieved 2019/05/16.
• 2、 -. "Imidazopyrazine compound, and preparation method and application thereof". Paragraph 0152; 0158; 0159. . Retrieved 2017/08/04.