5-(2-bromoethyl)-4-methylthiazole

Base Information

• Chemical Name: 5-(2-bromoethyl)-4-methylthiazole
• CAS No.: 671-24-9
• Molecular Formula: C6H8BrNS
• Molecular Weight: 206.106
• Mol file: 671-24-9.mol

Synonyms:5-(2-bromoethyl)-4-methylthiazole

Chemical Property of 5-(2-bromoethyl)-4-methylthiazole

Chemical Property:

• PSA: 41.13000
• LogP: 2.38890

Purity/Quality:

5-(2-Bromoethyl)-4-methyl-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-bromoethyl)-4-methylthiazole

There total 5 articles about 5-(2-bromoethyl)-4-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-hydroxyethyl-4-methylthiazole (137-00-8,8042-97-5) → 5-(2-bromoethyl)-4-methyl-1,3-thiazole (671-24-9)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 ℃; for 7h; Reflux;

DOI:10.1002/chem.202003454

Reference yield:

vitamin B1 (59-43-8) → 5-(2-bromoethyl)-4-methyl-1,3-thiazole (671-24-9)

Guidance literature:

With hydrogen bromide; In water; at 100 ℃; for 12h;

DOI:10.1016/0040-4020(96)00878-2

Reference yield:

2-(2-bromo-4-methyl-thiazol-5-yl)-ethanol (874509-37-2) → 5-(2-bromoethyl)-4-methyl-1,3-thiazole (671-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; aq.-ethanolic NaOH / Hydrogenation

2: PBr₃

With sodium hydroxide; palladium on activated charcoal; phosphorus tribromide;

upstream raw materials:

5-hydroxyethyl-4-methylthiazole

2-bromo-5-(2-bromo-ethyl)-4-methyl-thiazole

thiocarboxamide

3,5-Dibromo-2-pentanone

Downstream raw materials:

1-(4-methyl-thiazol-5-yl)-2-salicyloyloxy-ethane

5-hydroxyethyl-4-methylthiazole

N-(2-Fluoro-phenyl)-N-{1-[2-(4-methyl-thiazol-5-yl)-ethyl]-4-phenyl-piperidin-4-yl}-propionamide

N-(2-Fluoro-phenyl)-N-{4-(4-methyl-thiazol-2-yl)-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-propionamide

Refernces

• 1、 -. "Pyrimidinone Derivatives as Antimalarial Agents". Paragraph 0499; 0500; 0501; 0609; 0610; 0611. . Retrieved 2015/07/15.
• 2、 -. "PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS". Page/Page column 44. . Retrieved 2014/01/09.