Technology Process of 4,7-Dichloro-3-iodoquinoline
There total 9 articles about 4,7-Dichloro-3-iodoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trichlorophosphate;
for 4h;
Reflux;
- Guidance literature:
-
4,7-dichloroquinoline;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -70 ℃;
for 1h;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran; hexane;
for 1h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/acs.joc.7b02855
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; iodine monochloride
2: phosphoryl chloride
With
Iodine monochloride; acetic acid; trichlorophosphate;
DOI:10.1021/ja01216a044
