1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid

Base Information

• Chemical Name: 1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid
• CAS No.: 51175-07-6
• Molecular Formula: C₁₁H₁₈O₃
• Molecular Weight: 198.262
• Mol file: 51175-07-6.mol

Synonyms:1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid

Chemical Property of 1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid

There total 3 articles about 1-(1-hydroxycyclohexyl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H20O3 → 1-(1-Hydroxy-cyclohexyl)-cyclobutanecarboxylic acid (51175-07-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

methyl cyclobutanecarboxylate (765-85-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(1-Hydroxy-cyclohexyl)-cyclobutanecarboxylic acid (51175-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With water; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

Cyclobutanecarboxylic acid (3721-95-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(1-Hydroxy-cyclohexyl)-cyclobutanecarboxylic acid (51175-07-6)

Guidance literature:

Multistep reaction; (i) nBuLi, iPr₂NH, hexane, THF, (ii) /BRN= 385735/;

DOI:10.1021/jo00925a010

upstream raw materials:

Cyclobutanecarboxylic acid

cyclohexanone

methyl cyclobutanecarboxylate

Refernces