Nonapeptide-1

Base Information

• Chemical Name: Nonapeptide-1
• CAS No.: 158563-45-2
• Molecular Formula: C61H87N15O9S
• Molecular Weight: 1206.5
• UNII: 64W45420K5
• Nikkaji Number: J725.125D
• Wikidata: Q27263795
• Mol file: 158563-45-2.mol

Synonyms:Nonapeptide-1;158563-45-2;H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;White 05;Melanostatine 5;Nonapeptide-1 [INCI];Met-pro-phe-arg-trp-phe-lys-pro-val;64W45420K5;L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-;Nonapeptide-1 (acetate);(Met5,pro6,d-phe7,d-trp9,phe10)-alpha-msh (5-13);(S)-1-(L-methionyl)-N-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-6-amino-1-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide;MFCD00672435;Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-a-MSH (5-13);UNII-64W45420K5;HY-P0097;AC-31945;DS-19607;CS-0017927;153N-6;C72990;Q27263795

Chemical Property of Nonapeptide-1

Chemical Property:

• PKA: 13.32±0.46(Predicted)
• PSA: 413.34000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 6.21360
• Solubility.: soluble in water(≥0.1g/ml)
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 33
• Exact Mass: 1205.65319059
• Heavy Atom Count: 86
• Complexity: 2280

Purity/Quality:

99% ^*data from raw suppliers

H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCCN6C(=O)C(CCSC)N
• Isomeric SMILES: CC(C)[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC5=CC=CC=C5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCSC)N
• Description: Nonapeptide-1 is a skin lightening peptide, derived from the melanocyte stimulating hormone (MSH). It prevents the activity of tyrosine in the melanocytes, melanin synthesis inhibition and helps to even out your skin tone by lessening hyper-pigmentation. This process reduces the formation of unwanted pigmentation, allowing for the control over skin tone and brown spots.
• Uses: A skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.
• Biological Functions: 1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%