1-Isopropenyl-4-methoxybenzene

Base Information

• Chemical Name: 1-Isopropenyl-4-methoxybenzene
• CAS No.: 1712-69-2
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Hs Code.: 2909309090
• NSC Number: 89344
• DSSTox Substance ID: DTXSID60293411
• Nikkaji Number: J82.420H
• Wikidata: Q72485554
• Mol file: 1712-69-2.mol

Synonyms:1712-69-2;1-isopropenyl-4-methoxybenzene;1-Methoxy-4-(1-propen-2-yl)benzene;1-methoxy-4-prop-1-en-2-ylbenzene;1-methoxy-4-(prop-1-en-2-yl)benzene;Benzene,1-methoxy-4-(1-methylethenyl)-;Benzene, 1-methoxy-4-(1-methylethenyl)-;1-Isopropenyl-4-methoxy-benzene;Anisole, p-isopropenyl-;MFCD09414742;p-Isopropenylanisole;Pseudoestragole;ps-Estragole;NSC89344;para-isopropenylanisole;2-(p-Methoxyphenyl)propene;ghl.PD_Mitscher_leg0.11;2-(p-Methoxyphenyl)propylene;4-Methoxy-alpha-methylstyrene;1-Methoxy-4-isopropenylbenzene;SCHEMBL1792104;p-Methoxy-.alpha.-methylstyrene;4-Methoxy-.alpha.-methylstyrene;DTXSID60293411;Styrene, p-methoxy-alpha-methyl-;BAA71269;4-CH3OC6H4C(CH3)=CH2;Styrene, p-methoxy-.alpha.-methyl-;AC1342;NSC 89344;NSC-89344;AKOS013154145;CS-12718;SY204715;CS-0215143;EN300-227290;TRANS,TRANS-4-ETHYL-4-VINYL-BICYCLOHEXYL;A848849

Chemical Property of 1-Isopropenyl-4-methoxybenzene

Chemical Property:

• Vapor Pressure: 0.119mmHg at 25°C
• Melting Point: 32 °C
• Refractive Index: 1.503
• Boiling Point: 227.1 °C at 760 mmHg
• Flash Point: 83.7 °C
• PSA: 9.23000
• Density: 0.93g/cm³
• LogP: 2.72830
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 148.088815002
• Heavy Atom Count: 11
• Complexity: 132

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2,2-Trifluoro-1,1-dimethyl-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C1=CC=C(C=C1)OC

Technology Process of 1-Isopropenyl-4-methoxybenzene

There total 89 articles about 1-Isopropenyl-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 1-isopropenyl-4-methoxybenzene (1712-69-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; toluene; at 25 ℃;

DOI:10.1016/S0040-4039(01)02007-X

Reference yield: 88.0%

1-<α-(p-tolylsulfonyl)ethyl>-4-methoxybenzene (122948-71-4) + methylmagnesium bromide (75-16-1) → (4,4'-dimethyl-1,1'-biphenyl) (613-33-2) + 1-isopropenyl-4-methoxybenzene (1712-69-2)

Guidance literature:

With bis(triphenylphosphine)nickel(II) diiodide; tricyclohexylphosphine; In tetrahydrofuran; at 70 ℃; Inert atmosphere;

DOI:10.1002/anie.201205969

Reference yield: 81.0%

(E)-N′-(1-(4-methoxyphenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1228679-43-3) + methyl iodide (74-88-4) → 4-Methoxystyrene (637-69-4,24936-44-5) + 1-isopropenyl-4-methoxybenzene (1712-69-2)

Guidance literature:

(E)-N′-(1-(4-methoxyphenyl)ethylidene)-4-methylbenzenesulfonohydrazide; With dimesitylmagnesium; lithium chloride; In tetrahydrofuran; at 40 ℃; for 3h;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 1h;

With water-d2; In tetrahydrofuran;

DOI:10.1021/ol300652k

upstream raw materials:

methyl magnesium iodide

methyl 4-methoxybenzoate

ethyl 4-methoxybenzoate

2-(4-methoxyphenyl)propan-2-ol

Downstream raw materials:

2,5-Dimethoxy-2,5-bis-(4-methoxyphenyl)hexan

S-(α,α'-Dimethyl-4-methoxybenzyl)-N-acetyl-L-cystein-methylamid

1-tert-Butylamino-2-(4-methoxy-phenyl)-propan-2-ol

2-(4-methoxyphenyl)propan-1-ol

Refernces

• 1、 Wang, Maorong,Gao, Bao,Huang, Hanmin. "Catalytic nucleophilic addition of olefinic C-H bond to α,β-unsaturated-γ-lactams". . p. 5533 - 5536. Retrieved 2015.
• 2、 Boyer et al.. "". . p. 2075,2078. Retrieved 1975.
• 3、 Wang, Ye,Zheng, Lei,Shi, Xiaodong,Chen, Yunfeng. "1,3-Difunctionalization of β-alkyl nitroalkenes via combination of Lewis base catalysis and radical oxidation". supporting information. p. 886 - 889. Retrieved 2021/02/01.
• 4、 Yang, Hui-Yi,Yao, Ya-Hong,Chen, Ming,Ren, Zhi-Hui,Guan, Zheng-Hui. "Palladium-Catalyzed Markovnikov Hydroaminocarbonylation of 1,1-Disubstituted and 1,1,2-Trisubstituted Alkenes for Formation of Amides with Quaternary Carbon". supporting information. p. 7298 - 7305. Retrieved 2021/05/26.