Technology Process of 1-(5-broMopyridin-2-yl)cyclopropanaMine
There total 3 articles about 1-(5-broMopyridin-2-yl)cyclopropanaMine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethylmagnesium bromide; 2-Cyano-5-bromopyridine;
titanium(IV) isopropylate;
In
diethyl ether;
at -78 - 20 ℃;
for 1.58333h;
With
boron trifluoride diethyl etherate;
In
diethyl ether;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: thionyl chloride / 3 h / Reflux
1.2: 20 °C / Cooling with ice
2.1: trichlorophosphate / toluene / 2 h / Reflux
2.2: pH 12 / Cooling with ice
3.1: titanium(IV)isopropoxide / diethyl ether / 0.08 h / -78 °C
3.2: 1.5 h / -78 - 20 °C
3.3: 2 h / 20 °C
With
thionyl chloride; titanium(IV)isopropoxide; trichlorophosphate;
In
diethyl ether; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trichlorophosphate / toluene / 2 h / Reflux
1.2: pH 12 / Cooling with ice
2.1: titanium(IV)isopropoxide / diethyl ether / 0.08 h / -78 °C
2.2: 1.5 h / -78 - 20 °C
2.3: 2 h / 20 °C
With
titanium(IV)isopropoxide; trichlorophosphate;
In
diethyl ether; toluene;
