1-ethyl-Proline Methyl ester

Base Information

• Chemical Name: 1-ethyl-Proline Methyl ester
• CAS No.: 1224637-00-6
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Mol file: 1224637-00-6.mol

Synonyms:1-ethyl-Proline Methyl ester

Chemical Property of 1-ethyl-Proline Methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-ethyl-Proline Methyl ester

There total 7 articles about 1-ethyl-Proline Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-acetyl-proline methyl ester (27460-51-1) → methyl 1-ethylpyrrolidine-2-carboxylate (1224637-00-6,107599-40-6)

Guidance literature:

With (5-bromobenzo[b]thiophen-2-yl)boronic acid; phenylsilane; In toluene; at 130 ℃; for 36h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201304495

Reference yield: 72.0%

methyl 5-bromo-2-ethylaminovalerate → methyl 1-ethylpyrrolidine-2-carboxylate (1224637-00-6,107599-40-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 66.0%

1-ethylpyrrolidine (7335-06-0) + carbonic acid dimethyl ester (616-38-6) → methyl 1-ethylpyrrolidine-2-carboxylate (1224637-00-6,107599-40-6)

Guidance literature:

1-ethylpyrrolidine; With boron trifluoride diethyl etherate; Inert atmosphere;

carbonic acid dimethyl ester; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02992

upstream raw materials:

ethyl bromide

methyl pyrrolidine-2-carboxylate hydrochloride

N-acetyl-proline methyl ester

1-ethylpyrrolidine

Refernces

• 1、 -. "Preparation method of (s)-N-ethyl-2-aminomethylpyrrolidine". . . Retrieved 2020/06/05.
• 2、 -. "SUBSTITUTED BENZAMIDE MODULATORS OF DOPAMINE RECEPTOR". Page/Page column 12. . Retrieved 2010/05/13.