Octaethylene glycol

Base Information

• Chemical Name: Octaethylene glycol
• CAS No.: 5117-19-1
• Molecular Formula: C16H34O9
• Molecular Weight: 370.441
• Hs Code.: 2909499000
• European Community (EC) Number: 225-856-4
• DSSTox Substance ID: DTXSID3058618
• Nikkaji Number: J97.000J
• Wikidata: Q27120582
• Metabolomics Workbench ID: 56585
• Mol file: 5117-19-1.mol

Synonyms:Octaethylene glycol;5117-19-1;3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol;Octanethyl glycol;HO-PEG8-OH;2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol;C16H34O9;EINECS 225-856-4;MFCD00698694;12034-81-0;PE8;PED-diol (n=8);Octa-ethylene glycol;4gs9;PEG8;PEG-8;SCHEMBL45160;DTXSID3058618;CHEBI:44794;AMY19030;BCP33115;AKOS015839805;C16-H34-O9;HY-W050087;SB67136;s10681;AS-19695;BP-21369;SY024582;LS-191709;CS-0031650;FT-0635546;O0295;EN300-1590283;A829142;A871353;J-511381;Q27120582;3,6,9,12,15,18,21-Heptaoxatricosane-21,23-diol;2-[2-[2-[2-[2-[2-[2-(2-hydroxyethyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Chemical Property of Octaethylene glycol

Chemical Property:

• Vapor Pressure: 7.16E-11mmHg at 25°C
• Melting Point: 22 °C
• Refractive Index: 1.462
• Boiling Point: 471.5 °C at 760 mmHg
• PKA: 14.06±0.10(Predicted)
• Flash Point: 239 °C
• PSA: 105.07000
• Density: 1.115 g/cm³
• LogP: -0.91280
• Storage Temp.: -20°C
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 22
• Exact Mass: 370.22028266
• Heavy Atom Count: 25
• Complexity: 210

Purity/Quality:

98%,99%, ^*data from raw suppliers

Octaethylene glycol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(COCCOCCOCCOCCOCCOCCOCCO)O
• Description: Octanethylene glycol is a polymer consisting of ethylene glycol monomers and two terminal hydroxyl groups. The PEG chain increases the water solubility of a compound in aqueous media. Increasing the number of ethylene glycol units within the entire chain improves the solubility properties of the PEG linker.
• Uses: Octaethylene Glycol is part of a leaf extract (Murdannia Bracteata) which was shown to exhibit antioxidant, antimicrobial and anti-cancer properties.Octaethylene Glycol also shows potential application as functional hydraulic fluids. Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of Octaethylene glycol

There total 24 articles about Octaethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,27-diphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane (105891-54-1) → octaethylene glycol (5117-19-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 60 ℃; for 1.5h; under 75006 Torr;

Reference yield: 97.0%

1,1,1,27,27,27-hexaphenyl-2,5,8,11,14,17, 20,23,26-nonaoxaheptacosane (144270-98-4) → octaethylene glycol (5117-19-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In dichloromethane; at 25 ℃; for 96h; under 3040 Torr;

DOI:10.1021/jo00050a065

Reference yield: 96.0%

2-methyl-26-crown-9 (88099-82-5) → octaethylene glycol (5117-19-1) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With water; hydrogenchloride; In 1,4-dioxane; Rate constant; Equilibrium constant; Ambient temperature; effect of alkali-metal chlorides;

DOI:10.1039/P29830001121

upstream raw materials:

3-oxa-1,5-dichloropentane

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Tetraethylene glycol

ethylene glycol

Downstream raw materials:

octaethyleneglycol 3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate

hexadecylethylene glycol monomethylether

hexadecaethylene glycol

toluene-4-sulfonic acid 2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl ester

Refernces

• 1、 -. "Supramolecular compound nano-carrier as well as preparation method and application thereof". Paragraph 0104-0108. . Retrieved 2021/08/14.
• 2、 -. "PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof". Paragraph 0024-0026; 0036-0037. . Retrieved 2020/06/17.