8-Methoxy-4-quinolinecarboxylic acid

Base Information

• Chemical Name: 8-Methoxy-4-quinolinecarboxylic acid
• CAS No.: 1092288-64-6
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.197
• Mol file: 1092288-64-6.mol

Synonyms:8-Methoxy-4-quinolinecarboxylic acid

Chemical Property of 8-Methoxy-4-quinolinecarboxylic acid

Chemical Property:

• PSA: 59.42000
• LogP: 1.94160

Purity/Quality:

98.5% ^*data from raw suppliers

8-Methoxyquinoline-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Methoxy-4-quinolinecarboxylic acid

There total 2 articles about 8-Methoxy-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-1H-indole-2,3-dione (84575-27-9) + sodium pyruvate (113-24-6) → 8-Methoxyquinoline 4-carboxylic acid (1092288-64-6)

Guidance literature:

7-methoxy-1H-indole-2,3-dione; sodium pyruvate; With water; sodium hydroxide; at 110 ℃; for 0.25h; under 4500.45 Torr; Microwave irradiation;

In water; at 190 - 200 ℃; for 0.0833333h; under 12001.2 - 13501.4 Torr; Microwave irradiation;

DOI:10.1016/j.cclet.2009.09.012

Reference yield:

8-methoxy-quinoline-2,4-dicarboxylic acid → 8-Methoxyquinoline 4-carboxylic acid (1092288-64-6)

Guidance literature:

In water; at 190 - 200 ℃; for 0.0833333h; under 12001.2 - 13501.4 Torr; Microwave irradiation;

DOI:10.1016/j.cclet.2009.09.012

Reference yield:

8-Methoxyquinoline 4-carboxylic acid (1092288-64-6) → 5-bromo N-(4-(dimethylamino)benzyl)-8-methoxyquinoline-4-carboxamide (1589471-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / water; sulfuric acid

2: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide; methanol

With acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; sulfuric acid; water; N,N-dimethyl-formamide;

upstream raw materials:

7-methoxy-1H-indole-2,3-dione

sodium pyruvate

Downstream raw materials:

5-bromo N-(4-(dimethylamino)benzyl)-8-methoxyquinoline-4-carboxamide

5-(4-(dimethylamino)benzyl)-9-methoxy-4H-benzo[de][2,6]naphthyridine-4,6(5H)-dione

5-(4-(dimethylamino)benzyl)-9-hydroxy-4H-benzo[de][2,6]naphthyridine-4,6(5H)-dione

Refernces