D609

Base Information

• Chemical Name: D609
• CAS No.: 83373-60-8
• Molecular Formula: C11H16KOS2
• Molecular Weight: 267.47
• Hs Code.: 29333990
• European Community (EC) Number: 280-379-9
• ChEMBL ID: CHEMBL404954
• Nikkaji Number: J281.782I
• Pharos Ligand ID: 7K3ZUL53TFRD
• Mol file: 83373-60-8.mol

Synonyms:Carbonodithioicacid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt (9CI);D 609;O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate potassium salt;Potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate;

Chemical Property of D609

Chemical Property:

• Vapor Pressure: 0.00164mmHg at 25°C
• Boiling Point: 303.8 °C at 760 mmHg
• Flash Point: 137.5 °C
• Storage Temp.: 0-6°C
• Solubility.: H2O: 300 mg/mL
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 266.02013893
• Heavy Atom Count: 15
• Complexity: 271

Purity/Quality:

99% ^*data from raw suppliers

D609 ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC2C(C1)C3CC2CC3OC(=S)[S-].[K+]
• Description: D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; Ki = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.
• Uses: D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E-/- mice.