3-FORMYLBENZENESULFONYL CHLORIDE

Base Information

• Chemical Name: 3-FORMYLBENZENESULFONYL CHLORIDE
• CAS No.: 53460-88-1
• Molecular Formula: C₇H₅ClO₃S
• Molecular Weight: 204.634
• Mol file: 53460-88-1.mol

Synonyms:3-FORMYLBENZENESULFONYL CHLORIDE

Chemical Property of 3-FORMYLBENZENESULFONYL CHLORIDE

Chemical Property:

• Boiling Point: 333℃
• Flash Point: 155℃
• PSA: 59.59000
• Density: 1.485
• LogP: 2.50740

Purity/Quality:

98%min ^*data from raw suppliers

3-formylbenzenesulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FORMYLBENZENESULFONYL CHLORIDE

There total 5 articles about 3-FORMYLBENZENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

sodium hydroxy(phenyl)methanesulfonate (4657-12-9) → 3-formylbenzenesulfonyl chloride (53460-88-1)

Guidance literature:

With chlorosulfonic acid; potassium sulfate; In dichloromethane; at 25 - 30 ℃; for 28h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1021/acs.oprd.6b00170

Reference yield: 56.0%

sodium hydroxy(phenyl)methanesulfonate (4657-12-9) → 3-formylbenzenesulfonyl chloride (53460-88-1) + 4-dichloromethyl-benzenesulfonyl chloride (67627-96-7) + 3-dichloromethyl-benzenesulfonyl chloride

Guidance literature:

With chlorosulfonic acid; at 30 ℃; Temperature;

DOI:10.1021/acs.oprd.6b00170

Reference yield: 17.0%

benzaldehyde (100-52-7) → 3-formylbenzenesulfonyl chloride (53460-88-1) + 4-dichloromethyl-benzenesulfonyl chloride (67627-96-7) + 3-dichloromethyl-benzenesulfonyl chloride

Guidance literature:

With chlorosulfonic acid; In neat (no solvent); at 40 ℃; Solvent; Temperature;

DOI:10.1021/acs.oprd.6b00170

upstream raw materials:

2-phenyl-1,3-dioxolane

benzaldehyde

sodium hydroxy(phenyl)methanesulfonate

Downstream raw materials:

belinostat

Refernces

• 1、 Bao, Xuefei,Song, Dake,Qiao, Xuejun,Zhao, Xuan,Chen, Guoliang. "The Development of an Effective Synthetic Route of Belinostat". . p. 1482 - 1488. Retrieved 2016/08/30.