3,4-dimethoxybenzenepropanoyl chloride

Base Information

• Chemical Name: 3,4-dimethoxybenzenepropanoyl chloride
• CAS No.: 51842-87-6
• Molecular Formula: C₁₁H₁₃ClO₃
• Molecular Weight: 228.675
• Mol file: 51842-87-6.mol

Synonyms:3,4-dimethoxybenzenepropanoyl chloride

Chemical Property of 3,4-dimethoxybenzenepropanoyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dimethoxybenzenepropanoyl chloride

There total 3 articles about 3,4-dimethoxybenzenepropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-methoxycinnamic acid (2107-70-2) → 3-(3,4-dimethoxy-phenyl)-propionyl chloride (51842-87-6)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 22h;

DOI:10.1007/s10886-008-9432-4

Reference yield:

3-(3,4-dimethoxyphenyl)propanoic acid sodium salt → 3-(3,4-dimethoxy-phenyl)-propionyl chloride (51842-87-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm010145w

Reference yield:

→ 3-(3,4-dimethoxy-phenyl)-propionyl chloride (51842-87-6)

Guidance literature:

upstream raw materials:

3,4-methoxycinnamic acid

Downstream raw materials:

5,6-dimethoxy-1-indanone

5,6-dimethoxy-indan-1,2-dione-2-oxime

5,6-Dimethoxy-2-indanylamine

N-(5,6-dimethoxy-indan-2-yl)-2-phenyl-N-propyl-acetamide

Refernces

• 1、 Gu, Qiang-Shuai,Guo, Kai-Xin,Li, Zhong-Liang,Liu, Lin,Liu, Xin-Yuan,Tian, Yu,Yang, Chang-Jiang,Ye, Liu. "Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)?H/C(sp)?H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands". supporting information. p. 26710 - 26717. Retrieved 2021/11/18.
• 2、 Davidson, Samuel J.,Pilkington, Lisa I.,Dempsey-Hibbert, Nina C.,El-Mohtadi, Mohamed,Tang, Shiying,Wainwright, Thomas,Whitehead, Kathryn A.,Barker, David. "Modular synthesis and biological investigation of 5-hydroxymethyl dibenzyl butyrolactones and related lignans". . . Retrieved 2018/11/30.