Axitinib Impurity a

Base Information

• Chemical Name: Axitinib Impurity a
• CAS No.: 1347304-18-0
• Molecular Formula: C₂₂H₁₈N₄O₂S
• Molecular Weight: 402.477
• Mol file: 1347304-18-0.mol

Synonyms:Axitinib Impurity a;Axitinib Sulfoxide

Chemical Property of Axitinib Impurity a

Chemical Property:

• Boiling Point: 720.6±60.0 °C(Predicted)
• PKA: 11.70±0.40(Predicted)
• PSA: 106.95000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 4.91120
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

AxitinibSulfoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.
• Uses: Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Technology Process of Axitinib Impurity a

There total 1 articles about Axitinib Impurity a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

axitinib (319460-85-0,885126-40-9) → Axitinib sulfoxide (1347304-18-0)

Guidance literature:

With Cunninghamella echinulata; for 192h; Reagent/catalyst; Microbiological reaction;

DOI:10.1124/dmd.113.056531

upstream raw materials:

axitinib

Refernces