Technology Process of (R)-Bupropion Hydrochloride
There total 8 articles about (R)-Bupropion Hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R) bupropion trifluoroacetate;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
With
hydrogenchloride;
In
hexane; isopropyl alcohol;
- Guidance literature:
-
(R,R)-2-(tert-butylamino)-1-(3-chlorophenyl)propanol;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -70 - -60 ℃;
for 3.81667h;
With
triethylamine;
In
dichloromethane;
at -15 - -5 ℃;
With
hydrogenchloride;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / ethyl acetate; water / 0.17 h / 25 °C
2: CHIRACLCEL OD-H CSP / isopropyl alcohol; trifluoroacetic acid; hexane / Resolution of racemate
3: sodium hydrogencarbonate / ethyl acetate; water
With
sodium hydrogencarbonate;
In
hexane; water; ethyl acetate; isopropyl alcohol; trifluoroacetic acid;
