Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)-

Base Information

• Chemical Name: Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)-
• CAS No.: 162401-69-6
• Molecular Formula: C12H12F2O4
• Molecular Weight: 258.222
• Mol file: 162401-69-6.mol

Synonyms:Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)-

Chemical Property of Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)-

Chemical Property:

• Melting Point: 150 °C
• PSA: 55.76000
• LogP: 2.77500

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)-

There total 1 articles about Benzoic acid, 4-(cyclopropylMethoxy)-3-(difluoroMethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid (162401-69-6)

Guidance literature:

Reference yield: 95.0%

3,5-dichloro-4-aminopyridine (22889-78-7) + 3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid (162401-69-6) → roflumilast (162401-32-3)

Guidance literature:

3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid; With thionyl chloride; In toluene; for 2h; Reflux;

3,5-dichloro-4-aminopyridine; With sodium hydride; In tetrahydrofuran; at 15 - 20 ℃;

Reference yield: 68.0%

3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid (162401-69-6) + di-tert-butyl dicarbonate (24424-99-5) + methylamine hydrochloride (593-51-1) → C18H23F2NO5

Guidance literature:

3-(difluoromethoxy)-4-(cyclopropylmethoxy)-benzoic acid; methylamine hydrochloride; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

di-tert-butyl dicarbonate; With dmap; In acetonitrile; at 40 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201603068

Downstream raw materials:

roflumilast

Refernces