TH1338

Base Information

• Chemical Name: TH1338
• CAS No.: 1258494-60-8
• Molecular Formula: C22H21N3O4
• Molecular Weight: 391.42
• Mol file: 1258494-60-8.mol

Synonyms:TH1338

Chemical Property of TH1338

Chemical Property:

• Boiling Point: 721.7±60.0 °C(Predicted)
• PKA: 11.08±0.40(Predicted)
• PSA: 107.44000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 2.80540

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TH1338

There total 3 articles about TH1338 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

7-ethyl-14-nitro-camptothecin (1258494-58-4) → 7-ethyl-14-aminocamptothecin (1258494-60-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm101354u

Reference yield: 62.0%

→ 7-ethyl-14-aminocamptothecin (1258494-60-8)

Guidance literature:

Reference yield:

7-ethylcamptothecin (78287-27-1) → 7-ethyl-14-aminocamptothecin (1258494-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic anhydride / 1 h / 0 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic anhydride; In methanol;

DOI:10.1021/jm101354u

upstream raw materials:

7-ethyl-14-nitro-camptothecin

7-ethylcamptothecin

Refernces

• 1、 -. "CAMPTOTHECIN DERIVATIVES". Page/Page column 66. . Retrieved 2010/12/31.