(4-Methylpyrimidin-2-yl)methanamine dihydrochloride

Base Information

• Chemical Name: (4-Methylpyrimidin-2-yl)methanamine dihydrochloride
• CAS No.: 933682-85-0
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Hs Code.: 2933599090
• European Community (EC) Number: 802-055-3,853-950-0
• Mol file: 933682-85-0.mol

Synonyms:(4-Methylpyrimidin-2-yl)methanamine dihydrochloride;1390654-85-9;(4-methylpyrimidin-2-yl)methanamine;dihydrochloride;[(4-methyl-2-pyrimidinyl)methyl]amine dihydrochloride;MFCD22666535;AKOS022178114;SB55951;BS-35703;CS-0215527;EN300-257069;(4-Methylpyrimidin-2-yl)methanaminedihydrochloride;1-(4-Methyl-2-pyrimidinyl)methanamine dihydrochloride;Z2372278985;1-(4-Methyl-2-pyrimidinyl)methanamine dihydrochloride, AldrichCPR

Chemical Property of (4-Methylpyrimidin-2-yl)methanamine dihydrochloride

Chemical Property:

• PSA: 51.80000
• LogP: 0.94400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 195.0330028
• Heavy Atom Count: 11
• Complexity: 84.4

Purity/Quality:

98%min ^*data from raw suppliers

C-(4-Methyl-pyrimidin-2-yl)-methylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NC(=NC=C1)CN.Cl.Cl

Technology Process of (4-Methylpyrimidin-2-yl)methanamine dihydrochloride

There total 2 articles about (4-Methylpyrimidin-2-yl)methanamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Cyan-4-methylpyrimidin (77768-02-6) → (4-methylpyrimidin-2-yl)methanamine (933682-85-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 3h;

Reference yield:

2-chloro-4-methylpyrimidine (13036-57-2) → (4-methylpyrimidin-2-yl)methanamine (933682-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 180 °C / Microwave irradiation; Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h

With hydrogen; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-Cyan-4-methylpyrimidin

2-chloro-4-methylpyrimidine

Refernces

• 1、 -. "(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING". Page/Page column 84. . Retrieved 2009/05/29.