Z-BETA-ALA-OME

Base Information

• Chemical Name: Z-BETA-ALA-OME
• CAS No.: 54755-77-0
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Hs Code.: 2924299090
• Mol file: 54755-77-0.mol

Synonyms:METHYL 3-(BENZYLOXY CARBONYLAMINO)-PROPANOATE;3-AMINO-3-CARBOBENZOXY-O-METHYL-PROPIONIC ACID;N-BETA-CARBOBENZOXY-BETA-ALANINE METHYL ESTER;Z-BETA-ALANINE METHYL ESTER;Z-BETA-ALA-OME;Z-GLY(C*CH2)-OME;Z-b-Ala-OMe;methyl 3-(benzyloxycarbonyl)propanoate

Chemical Property of Z-BETA-ALA-OME

Chemical Property:

• PSA: 68.12000
• LogP: 1.68030
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl3-([(benzyloxy)carbonyl]amino)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-([(benzyloxy)carbonyl]amino)propanoate

Technology Process of Z-BETA-ALA-OME

There total 17 articles about Z-BETA-ALA-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → N-benzyloxycarbonyl-3-aminopropionic acid methyl ester (54755-77-0)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2012.03.072

Reference yield: 75.0%

methanol (67-56-1) + 1-diazo-3-(N-benzyloxycarbonyl)amino-2-propanone (67865-70-7) → N-benzyloxycarbonyl-3-aminopropionic acid methyl ester (54755-77-0)

Guidance literature:

With silver benzoate; triethylamine; at -25 - 20 ℃; for 3h; Inert atmosphere; Darkness;

DOI:10.1128/AAC.01152-16

Reference yield: 70.0%

methyl 3,3-dimethoxypropionate (7424-91-1) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-3-aminopropionic acid methyl ester (54755-77-0)

Guidance literature:

With triethylsilane; 1,1,1,3,3,3-hexamethyl-disilazane; iron(II) sulfate; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/ejoc.200700627

upstream raw materials:

methanol

N-[(phenylmethoxy)carbonyl]-β-alanine chloride

2-methoxycarbonylethyl isocyanate

benzyl alcohol

Downstream raw materials:

3-(benzyloxycarbonylamino)propanoic acid

N^β-benzyloxycarbonyl-β-alaninamide

benzyl N-[2-(hydrazinecarbonyl)ethyl]carbamate

3-[(N-benzyloxycarbonyl)amino]propanol

Refernces

• 1、 Szewczyk, Suzanne M.,Zhao, Yizhou,Sakai, Holt A.,Dube, Pascal,Newhouse, Timothy R.. "α,β-Dehydrogenation of esters with free O–H and N–H functionalities via allyl-palladium catalysis". . p. 3293 - 3300. Retrieved 2018/03/21.
• 2、 Andreini, Manuel,Felten, Anne-Sophie,Thien, Hoang-Trang Tran,Taillefumier, Claude,Pellegrini-Mo?se, Nadia,Chapleur, Yves. "Synthesis of new C-glycosyl aza-β3-amino acids building blocks". scheme or table. p. 2702 - 2705. Retrieved 2012/07/27.