ML 141

Base Information

• Chemical Name: ML 141
• CAS No.: 71203-35-5
• Molecular Formula: C22H21N3O3S
• Molecular Weight: 407.493
• Mol file: 71203-35-5.mol

Synonyms:4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide;CID-2950007;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline

Chemical Property of ML 141

Chemical Property:

• Melting Point: 216 °C(Solv: ethanol (64-17-5))
• Boiling Point: 622.9±65.0 °C(Predicted)
• PKA: 10.39±0.10(Predicted)
• PSA: 93.37000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 4.98000
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL (warmed, clear solution)

Purity/Quality:

98%,99%, ^*data from raw suppliers

ML 141 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: ML 141 has been used:to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cellsas inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nucleias actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondriaas a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Technology Process of ML 141

There total 7 articles about ML 141 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide (71203-35-5)

Guidance literature:

In ethanol; for 4h; Heating;

Reference yield: 65.0%

4-aminosulfonylphenylhydrazine (4392-54-5) + 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one (959-33-1) → 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide (71203-35-5)

Guidance literature:

In ethanol; for 3h; Heating;

Reference yield: 65.0%

4-{N'-[(E)-3-(4-Methoxy-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide (122259-16-9) → 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide (71203-35-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 2h; Heating;

upstream raw materials:

4-{N'-[(E)-3-(4-Methoxy-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide

4-aminosulfonylphenylhydrazine

3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

4-hydrazinobenzene-1-sulfonamide hydrochloride

Downstream raw materials:

4-[5-(4-Methoxy-phenyl)-3-phenyl-pyrazol-1-yl]-benzenesulfonamide

C₂₉H₃₂N₄O₃S₂

4-[4-Bromo-5-(4-methoxy-phenyl)-3-phenyl-pyrazol-1-yl]-benzenesulfonamide

C₂₆H₂₄N₄O₃S₂

Refernces

• 1、 -. "Modulators of GTPase and Use In Relevant Treatment". Paragraph 0135. . Retrieved 2014/02/15.
• 2、 Feid-Allah. "Trisubstituted pyrazoles of possible antidiabetic and antibacterial activity". . p. 754 - 756. Retrieved 2007/10/02.