Technology Process of 6-Chloro-9-(2-deoxy-2-fluororibofuranosyl)purine
There total 8 articles about 6-Chloro-9-(2-deoxy-2-fluororibofuranosyl)purine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 69 percent / imidazole / dimethylformamide / 1 h / Ambient temperature
2: 69 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 0.5 h / Ambient temperature
3: 78 percent / dimethylformamide / Ambient temperature
4: 60 percent / tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 0.17 h / 0 °C
5: 3.9 g / p-toluenesulfonic acid / dimethylformamide / 2 h / Ambient temperature
6: 95 percent / ammonia / methanol / 3 h / 0 °C
7: 50 percent / diethylaminosulfur trifluoride, pyridine / CH2Cl2 / 6 h / Ambient temperature
8: 68 percent / pyridinium p-toluenesulfonate / ethanol / 8 h / 50 °C
With
pyridine; 1H-imidazole; dmap; diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; ammonia; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013260
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3.9 g / p-toluenesulfonic acid / dimethylformamide / 2 h / Ambient temperature
2: 95 percent / ammonia / methanol / 3 h / 0 °C
3: 50 percent / diethylaminosulfur trifluoride, pyridine / CH2Cl2 / 6 h / Ambient temperature
4: 68 percent / pyridinium p-toluenesulfonate / ethanol / 8 h / 50 °C
With
pyridine; diethylamino-sulfur trifluoride; ammonia; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/15257779408013260