1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate

Base Information

• Chemical Name: 1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate
• CAS No.: 1221818-73-0
• Molecular Formula: C₁₇H₂₁NO₆
• Molecular Weight: 335.357
• Hs Code.: 2933399090
• Mol file: 1221818-73-0.mol

Synonyms:1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate;1-benzyl 3,5-diMethyl piperidine-1,3,5-tricarboxylate

Chemical Property of 1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate

Chemical Property:

• Boiling Point: 451.9±45.0 °C(Predicted)
• PKA: -3.73±0.60(Predicted)
• PSA: 82.14000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 1.54520

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl3,5-dimethylpiperidine-1,3,5-tricarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate

There total 3 articles about 1-Benzyl 3,5-diMethyl piperidin-1,3,5-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + dimethyl piperidine-3,5-dicarboxylate (54732-79-5) → 1-benzyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate (1221818-73-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 15 ℃; for 6h;

Reference yield:

3,5-Pyridinedicarboxylic acid (499-81-0) → 1-benzyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate (1221818-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 12 h / 60 °C

2: hydrogen; palladium on activated charcoal / methanol; acetic acid / 48 h / 50 °C / 2327.23 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 15 °C

With thionyl chloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetic acid;

Reference yield:

dimethyl pyridine-3,5-dicarboxylate (4591-55-3) → 1-benzyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate (1221818-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol; acetic acid / 48 h / 50 °C / 2327.23 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 15 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetic acid;

upstream raw materials:

benzyl chloroformate

dimethyl piperidine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid

dimethyl pyridine-3,5-dicarboxylate

Downstream raw materials:

1-benzyl 3-methyl 5-((tert-butoxycarbonyl)amino)piperidine-1,3-dicarboxylate

N-Cbz-3-hydroxymethylpiperidine

tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate

(3R,5S)-Piperidine-1,3,5-tricarboxylic acid 1-benzyl ester 3-methyl ester

Refernces