N(1),N(8)-diethylspermidine

Base Information

• Chemical Name: N(1),N(8)-diethylspermidine
• CAS No.: 97141-40-7
• Molecular Formula: C₁₁H₂₇N₃
• Molecular Weight: 201.355
• Mol file: 97141-40-7.mol

Synonyms:1,4-Butanediamine,N-ethyl-N'-[3-(ethylamino)propyl]- (9CI); N1,N8-Bis(ethyl)spermidine;N1,N8-Diethylspermidine

Chemical Property of N(1),N(8)-diethylspermidine

Chemical Property:

• Boiling Point: 292.1°Cat760mmHg
• Flash Point: 128.1°C
• PSA: 0.00000
• Density: 0.851g/cm³
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N(1),N(8)-diethylspermidine

There total 3 articles about N(1),N(8)-diethylspermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1,N8-diethyl-N1,N4,N8-tris(mesitylenesulfonyl)spermidine (189340-59-8) → 1,8-di(ethylamino)-4-azaoctane (97141-40-7)

Guidance literature:

With hydrogen bromide; phenol; In dichloromethane; acetic acid; for 24h; Ambient temperature;

DOI:10.1021/jm960849j

Reference yield:

spermidine trihydrochloride (334-50-9,35408-56-1) → 1,8-di(ethylamino)-4-azaoctane (97141-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / 1 N aq. NaOH / CH₂Cl₂ / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 65 deg C, 12 h

3: HBr, phenol / acetic acid; CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; sodium hydride; phenol; In dichloromethane; acetic acid;

DOI:10.1021/jm960849j

Reference yield:

N1,N4,N8-tris(mesitylenesulfonyl)spermidine (189340-47-4) → 1,8-di(ethylamino)-4-azaoctane (97141-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 65 deg C, 12 h

2: HBr, phenol / acetic acid; CH₂Cl₂ / 24 h / Ambient temperature

With hydrogen bromide; sodium hydride; phenol; In dichloromethane; acetic acid;

DOI:10.1021/jm960849j

upstream raw materials:

N¹,N⁸-diethyl-N¹,N⁴,N⁸-tris(mesitylenesulfonyl)spermidine

spermidine trihydrochloride

N¹,N⁴,N⁸-tris(mesitylenesulfonyl)spermidine

Refernces