5-cyano-2-Methylisonicotinic acid

Base Information

• Chemical Name: 5-cyano-2-Methylisonicotinic acid
• CAS No.: 859970-50-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.148
• Hs Code.: 2933399090
• Mol file: 859970-50-6.mol

Synonyms:5-cyano-2-Methylisonicotinic acid

Chemical Property of 5-cyano-2-Methylisonicotinic acid

Chemical Property:

• PSA: 73.98000
• LogP: 0.95988
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

5-Cyano-2-methylisonicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyano-2-Methylisonicotinic acid

There total 3 articles about 5-cyano-2-Methylisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-2-methyl-isonicotinic acid ethyl ester (90915-26-7) → 5-cyano-2-methyl-isonicotinic acid (859970-50-6)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jo01197a010

Reference yield:

ethyl 2-chloro-3-cyano-6-methyl-4-pyridine carboxylate (40108-12-1) → 5-cyano-2-methyl-isonicotinic acid (859970-50-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/BaCO₃; ethanol / Hydrogenation

2: ethanolic NaOH

With sodium hydroxide; palladium-barium carbonate; ethanol;

DOI:10.1021/jo01197a010

Reference yield:

ethyl 3-cyano-2-hydroxy-6-methylisonicotinate (18619-97-1) → 5-cyano-2-methyl-isonicotinic acid (859970-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1: PCl₅; POCl₃

2: palladium/BaCO₃; ethanol / Hydrogenation

3: ethanolic NaOH

With sodium hydroxide; palladium-barium carbonate; ethanol; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/jo01197a010

upstream raw materials:

5-cyano-2-methyl-isonicotinic acid ethyl ester

ethyl 2-chloro-3-cyano-6-methyl-4-pyridine carboxylate

ethyl 3-cyano-2-hydroxy-6-methylisonicotinate