Hydroxy Varenicline N-Trifluoroacetate

Base Information

• Chemical Name: Hydroxy Varenicline N-Trifluoroacetate
• CAS No.: 357426-10-9
• Molecular Formula: C₁₅H₁₂F₃N₃O₂
• Molecular Weight: 323.274
• Mol file: 357426-10-9.mol

Synonyms:Hydroxy Varenicline N-Trifluoroacetate;1,6,7,8,9,10-Hexahydro-8-(trifluoroacetyl)-6,10-Methano-2H-pyrazino[2,3-h][3]benzazepin-2-one;Hydroxy Varenicline N-Trifluoroacetic Acid Salt

Chemical Property of Hydroxy Varenicline N-Trifluoroacetate

Chemical Property:

• PSA: 66.06000
• LogP: 1.83640
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy Varenicline N-Trifluoroacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Protected Varenicline metabolite.

Technology Process of Hydroxy Varenicline N-Trifluoroacetate

There total 1 articles about Hydroxy Varenicline N-Trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(7,8-diamino-4,5-dihydro-1H-1,5-methanobenzo[d]azepin-3(2H)-yl)-2,2,2-trifluoroethanone (230615-69-7) + Glyoxilic acid (298-12-4) → C15H12F3N3O2 (357426-10-9)

Guidance literature:

In water; at 80 ℃;

DOI:10.1016/j.bmcl.2005.08.035

Reference yield: 95.0%

C15H12F3N3O2 (357426-10-9) → C13H13N3O (357424-21-6,357424-81-8,357425-48-0)

Guidance literature:

With sodium carbonate; In methanol;

DOI:10.1016/j.bmcl.2005.08.035

upstream raw materials:

1-(7,8-diamino-4,5-dihydro-1H-1,5-methanobenzo[d]azepin-3(2H)-yl)-2,2,2-trifluoroethanone

Glyoxilic acid

Downstream raw materials:

C₁₃H₁₃N₃O

Refernces