2-Chloro-6-methylpyridine-4-carboxylic acid

Base Information

• Chemical Name: 2-Chloro-6-methylpyridine-4-carboxylic acid
• CAS No.: 25462-85-5
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 29333990
• Mol file: 25462-85-5.mol

Synonyms:Isonicotinicacid, 2-chloro-6-methyl- (6CI,8CI);2-Chloro-6-methyl-4-pyridinecarboxylicacid;2-Chloro-6-methylisonicotinic acid;

Chemical Property of 2-Chloro-6-methylpyridine-4-carboxylic acid

Chemical Property:

• Appearance/Colour: brown solid
• Vapor Pressure: 4.39E-07mmHg at 25°C
• Melting Point: 208-212 °C (dec.)(lit.)
• Refractive Index: 1.578
• Boiling Point: 399 °C at 760 mmHg
• PKA: 3.07±0.10(Predicted)
• Flash Point: 195.1 °C
• PSA: 50.19000
• Density: 1.39 g/cm³
• LogP: 1.74160
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-methylpyridine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-20/21/22
• Safety Statements: 26-36/37/39-22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Chloro-6-methylpyridine-4-carboxylic acid

There total 7 articles about 2-Chloro-6-methylpyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid (86454-13-9) → 2-chloro-6-methylpyridine-4-carboxylic acid (25462-85-5)

Guidance literature:

With trichlorophosphate; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2012.05.096

Reference yield:

2-chloro-6-methyl-isonicotinic acid methyl ester (3998-90-1) → 2-chloro-6-methylpyridine-4-carboxylic acid (25462-85-5)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01512a050

Reference yield:

methyl 6-methyl-2-hydroxypyridine-4-carboxylate (98491-78-2) → 2-chloro-6-methylpyridine-4-carboxylic acid (25462-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅

2: ethanolic KOH

With potassium hydroxide; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01512a050

upstream raw materials:

2-chloro-6-methyl-isonicotinic acid methyl ester

2-chloro-4,6-dimethyl-pyridine

methyl 6-methyl-2-hydroxypyridine-4-carboxylate

1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid

Downstream raw materials:

2-chloro-6-methyl-isonicotinic acid methyl ester

2-chloro-6-methylisonicotinic acid ethyl ester

2-Chlor-6-methyl-isonicotinsaeureamid

(2-chloro-6-methylpyridin-4-yl)(3,5-dibromophenyl)methanone

Refernces