quinoline-2,4-diol

Base Information

• Chemical Name: quinoline-2,4-diol
• CAS No.: 70254-44-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Mol file: 70254-44-3.mol

Synonyms:2-Hydroxyquinolin-4(1H)-one

Chemical Property of quinoline-2,4-diol

Chemical Property:

• Melting Point: >330 °C (sublm)(Solv: acetic acid (64-19-7))
• Boiling Point: 303.8±42.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 53.09000
• Density: 1.376±0.06 g/cm3(Predicted)
• LogP: 1.23370

Purity/Quality:

98.5% ^*data from raw suppliers

2-Hydroxyquinolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of quinoline-2,4-diol

There total 71 articles about quinoline-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (40059-53-8) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate; With water; potassium hydroxide; Reflux;

In water; Acidic conditions;

DOI:10.1021/jo9011915

Reference yield: 99.1%

1H-4-hydroxy-2-oxoquinoline-3-carboxylic acid methyl ester (73776-19-9) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

With potassium hydroxide; In water; for 15h; Heating;

Reference yield: 99.0%

malonanilic acid (15580-32-2) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

With aluminum (III) chloride; Eaton′s reagent; at 90 ℃; for 6h; Reagent/catalyst; Mechanism; Inert atmosphere;

upstream raw materials:

1-(Chloroacetyl)-1H-indole-2,3-dione

water

quinoline

1H-indene-1,3(2H)-dione

Downstream raw materials:

4-amino-quinolin-2-ol

2-(oxalamino)benzoic acid

4-hydroxy-3-acetyl-1H-quinoline-2-one

2,4-dichloro-3-phenylsulfanyl-quinoline

Refernces

• 1、 -. "Thiophene quinolone compound as well as preparation method and application thereof". Paragraph 0070; 0088; 0092-0093. . Retrieved 2021/09/26.
• 2、 Elbastawesy, Mohammed A. I.,El-Shaier, Yaseen A. M. M.,Ramadan, Mohamed,Brown, Alan B.,Aly, Ashraf A.,Abuo-Rahma, Gamal El-Din A.. "Identification and molecular modeling of new quinolin-2-one thiosemicarbazide scaffold with antimicrobial urease inhibitory activity". . p. 13 - 27. Retrieved 2020/01/22.