N-Cyclohexyl-N-methylcyclohexanamine

Base Information

• Chemical Name: N-Cyclohexyl-N-methylcyclohexanamine
• CAS No.: 7560-83-0
• Molecular Formula: C13H25 N
• Molecular Weight: 195.348
• Hs Code.: 29213000
• European Community (EC) Number: 231-453-4
• NSC Number: 166513
• UNII: RI95G6J8FF
• DSSTox Substance ID: DTXSID6044727
• Nikkaji Number: J87.276H
• Wikidata: Q26840871
• ChEMBL ID: CHEMBL3186353
• Mol file: 7560-83-0.mol

Synonyms:N-Cyclohexyl-N-methylcyclohexanamine;7560-83-0;N,N-Dicyclohexylmethylamine;N-Methyldicyclohexylamine;Cyclohexanamine, N-cyclohexyl-N-methyl-;Dicyclohexylamine, N-methyl-;methyldicyclohexylamine;HSDB 4370;N-METHYL DICYCLOHEXYLAMINE;N-Cyclohexyl-N-methylcyclohexylamine;Cy2NMe;EINECS 231-453-4;N-methyl-dicyclohexylamine;N-cyclohexyl-N-methyl-cyclohexanamine;N,N-Dicyclohexymethylamine;UNII-RI95G6J8FF;NSC 166513;BRN 2074991;RI95G6J8FF;DTXSID6044727;NSC-166513;4-12-00-00023 (Beilstein Handbook Reference);NN-Dicyclohexylmethylamine;MeNCy2;dicyclohexyl methylamine;dicyclohexyl-methylamine;methyl dicyclohexylamine;di-cyclohexyl-methylamine;dicyclohexyl methyl amine;dicyclohexyl(methyl)amine;dicyclohexyl-methyl-amine;n-methyldicyclohexyl amine;N -methyldicyclohexylamine;SCHEMBL15013;N,N-dicyclohexyl-methyl-amine;N-N Dicyclohexyl methyl amine;CHEMBL3186353;DTXCID4024727;GSCCALZHGUWNJW-UHFFFAOYSA-;CHEBI:183431;METHYLDICYCLOHEXYLAMINE, N-;N,N-Dicyclohexylmethylamine, 97%;WLN: L6TJ AN1&- AL6TJ;4-Fluorobiphenyl-4-sulfonylchloride;N-methyl-N-cyclohexylcyclohexylamine;Tox21_301508;MFCD00014289;N-cyclohexyl-N-methylcyclo-hexanamine;NSC166513;AKOS015850720;N-Cyclohexyl-N-methylcyclohexanamine #;CS-W010618;GS-3422;N-METHYL DICYCLOHEXYLAMINE [HSDB];NCGC00256070-01;LS-61775;CAS-7560-83-0;D0820;FT-0629455;D70351;EN300-7356695;A865653;W-104391;Q26840871

Chemical Property of N-Cyclohexyl-N-methylcyclohexanamine

Chemical Property:

• Appearance/Colour: clear to yellow liquid
• Vapor Pressure: 0.0107mmHg at 25°C
• Melting Point: 193-194 °C
• Refractive Index: n20/D 1.49(lit.)
• Boiling Point: 265 C
• PKA: 11.03±0.20(Predicted)
• Flash Point: 110 ºC
• PSA: 3.24000
• Density: 0.912
• LogP: 3.58360
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: 740mg/L at 25℃
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 195.198699802
• Heavy Atom Count: 14
• Complexity: 137

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dicyclohexylmethylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN(C1CCCCC1)C2CCCCC2
• Uses: N,N-Dicyclohexylmethylamine is used as a reagent in the base preparation of 13C2- and 2H phenethylamines as internal standards for IDMS by Pd-catalyzed double carbonylation of aryl iodides in the presence of amine nucleophiles followed by deoxygenation. N,N-Dicyclohexylmethylamine has been employed as:catalyst during O-phenylation of tertiary alcohol with organobismuth(V) compoundsbase during Pd-catalyzed 5-endo-trig cyclization of 1-(o-bromophenyl)-2-methylprop-2-en-1-ol

Technology Process of N-Cyclohexyl-N-methylcyclohexanamine

There total 25 articles about N-Cyclohexyl-N-methylcyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-cyclohexyl-cyclohexanamine (101-83-7) → N-Methyldicyclohexylamine (7560-83-0)

Guidance literature:

chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); at 100 ℃;

Reference yield: 99.0%

→ N-Methyldicyclohexylamine (7560-83-0)

Guidance literature:

With 5percent silver supported on titanium oxide; at 25 ℃; for 10h; Inert atmosphere; Sealed tube; UV-irradiation;

Reference yield: 96.0%

N,N-dimethyldicyclohexylamine iodide (7209-57-6) → N-Methyldicyclohexylamine (7560-83-0)

Guidance literature:

With disodium telluride; In ethanol; Heating;

DOI:10.1016/S0040-4039(00)95051-2

upstream raw materials:

N-methylaniline hydrochloride

N-Methylformamide

cyclohexanone

N,N-dimethyl-aniline

Downstream raw materials:

N-nitrosodicyclohexylamine

C₁₃H₂₅N*C₃₀H₃₂N₆O₆

hydroquinone radical

C₇H₁₄NO

Refernces

• 1、 Sarki, Naina,Goyal, Vishakha,Tyagi, Nitin Kumar,Puttaswamy,Narani, Anand,Ray, Anjan,Natte, Kishore. "Simple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol". . p. 1722 - 1729. Retrieved 2021/04/19.
• 2、 You, Wei,Hugar, Kristina M.,Selhorst, Ryan C.,Treichel, Megan,Peltier, Cheyenne R.,Noonan, Kevin J. T.,Coates, Geoffrey W.. "Degradation of Organic Cations under Alkaline Conditions". supporting information. p. 254 - 263. Retrieved 2020/12/23.