1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI)

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI)
• CAS No.: 125787-05-5
• Molecular Formula: C6H11NO3
• Molecular Weight: 145.16
• Mol file: 125787-05-5.mol

Synonyms:1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI);(R)-3-hydroxy-1-Pyrrolidinecarboxylic acid Methyl ester

Chemical Property of 1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI)

Chemical Property:

• Boiling Point: 240.5±33.0 °C(Predicted)
• PKA: 14.73±0.20(Predicted)
• PSA: 49.77000
• Density: 1.269±0.06 g/cm3(Predicted)
• LogP: -0.24270

Purity/Quality:

(R)-3-hydroxy-1-Pyrrolidinecarboxylicacidmethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI)

There total 1 articles about 1-Pyrrolidinecarboxylicacid,3-hydroxy-,methylester,(R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3R)-pyrrolidinol (40499-83-0,83220-72-8,100243-39-8,2799-21-5) + methyl chloroformate (79-22-1) → (3R)-1-methoxycarbonylpyrrolidin-2-ol (125787-05-5)

Guidance literature:

With triethylamine; In dichloromethane; for 3h;

Reference yield: 100.0%

meta-nitrophenol (554-84-7) + (3R)-1-methoxycarbonylpyrrolidin-2-ol (125787-05-5) → methyl (3S)-3-(3-nitrophenoxy)pyrrolidine-1-carboxylate (741290-76-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmc.2004.05.032

Reference yield:

(3R)-1-methoxycarbonylpyrrolidin-2-ol (125787-05-5) → methyl (3S)-3-(3-aminophenoxy)pyrrolidine-1-carboxylate (741290-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

2: 2.09 g / H₂ / Pd/C / methanol / 3 h / atmosperic pressure

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmc.2004.05.032

upstream raw materials:

(3R)-pyrrolidinol

methyl chloroformate

Downstream raw materials:

methyl (3S)-3-(3-nitrophenoxy)pyrrolidine-1-carboxylate

methyl (3S)-3-(3-aminophenoxy)pyrrolidine-1-carboxylate

Refernces