3-BroMo-4-(tert-butyl)aniline

Base Information

• Chemical Name: 3-BroMo-4-(tert-butyl)aniline
• CAS No.: 103275-21-4
• Molecular Formula: C10H14BrN
• Molecular Weight: 228.132
• Hs Code.: 2921420090
• Mol file: 103275-21-4.mol

Synonyms:3-BroMo-4-(tert-butyl)aniline

Chemical Property of 3-BroMo-4-(tert-butyl)aniline

Chemical Property:

• Melting Point: 29-29.5 °C
• Boiling Point: 125 °C(Press: 1 Torr)
• PKA: 3.85±0.10(Predicted)
• PSA: 26.02000
• Density: 1.306±0.06 g/cm3(Predicted)
• LogP: 3.91000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

3-Bromo-4-(tert-butyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BroMo-4-(tert-butyl)aniline

There total 8 articles about 3-BroMo-4-(tert-butyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-1-tert-butyl-4-nitrobenzene (6310-17-4) → 3-bromo-4-(tert-butyl)aniline (103275-21-4)

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 3h;

Reference yield:

tert-butylbenzene (253185-03-4,253185-04-5) → 3-bromo-4-(tert-butyl)aniline (103275-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / 3 h / 20 - 40 °C

2: sulfuric acid; N-Bromosuccinimide; trifluoroacetic acid / 24 h / 20 °C

3: hydrogenchloride; iron / water; ethanol / 2 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; nitric acid; iron; trifluoroacetic acid; In ethanol; water;

DOI:10.1002/asia.201900821

Reference yield:

4-tert-butylnitrobenzene (3282-56-2) → 3-bromo-4-(tert-butyl)aniline (103275-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; N-Bromosuccinimide; trifluoroacetic acid / 24 h / 20 °C

2: hydrogenchloride; iron / water; ethanol / 2 h / Reflux

With hydrogenchloride; N-Bromosuccinimide; sulfuric acid; iron; trifluoroacetic acid; In ethanol; water;

DOI:10.1002/asia.201900821

upstream raw materials:

3-bromo-4-tert-butyl-benzoic acid amide

3-bromo-4-(tert-butyl)benzoic acid

4-(1,1-dimethylethyl)benzoic acid

2-bromo-1-tert-butyl-4-nitrobenzene

Downstream raw materials:

2-tert-butylbromobenzene

2-tert-butylbenzoic acid

2,4-dibromo-1-tert-butyl-benzene

3-bromo-4-(tert-butyl)phenol

Refernces

• 1、 -. "METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS". Page/Page column 247. . Retrieved 2010/02/13.