Betulin-3-acetate

Base Information

• Chemical Name: Betulin-3-acetate
• CAS No.: 27570-20-3
• Molecular Formula: C32H52O3
• Molecular Weight: 484.763
• Mol file: 27570-20-3.mol

Synonyms:Betulin-3-acetate;3β-Acetoxylupa-20(29)-ene-28-ol;Betulin monoacetate;Lup-20(29)-ene-3β,28-diol 3-acetate;Lupane-20(29)-ene-3β,28-diol 3-acetate

Chemical Property of Betulin-3-acetate

Chemical Property:

• PSA: 46.53000
• LogP: 7.56800

Purity/Quality:

3-Acetylbetulin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Betulin-3-acetate

There total 4 articles about Betulin-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

betulin diacetate (1721-69-3) → betulin (473-98-3) + betulin monoacetate (27570-20-3)

Guidance literature:

With calcium hydroxide; In methanol; chloroform; for 24h; Ambient temperature;

Reference yield: 14.0%

betulin (473-98-3) + ethyl acetate (141-78-6) → betulin diacetate (1721-69-3) + betulin monoacetate (27570-20-3) + 28-acetoxybetulin (27686-35-7)

Guidance literature:

With sodium hydrogen sulfate; silica gel; In hexane; at 50 ℃; for 72h;

DOI:10.1021/jo971367y

Reference yield:

betulin (473-98-3) + acetic anhydride (108-24-7) → betulin diacetate (1721-69-3) + betulin monoacetate (27570-20-3)

Guidance literature:

With dmap; lupenol; In acetone; for 2h;

DOI:10.1055/s-2000-8534

upstream raw materials:

betulin diacetate

betulin

ethyl acetate

acetic anhydride

Downstream raw materials:

lupeol acetate

methyl betulinate

Acetylmethylbetulinate

betulinic aldehyde

Refernces

• 1、 Koenig, Gabriele M.,Wright, Anthony D.,Franzblau, Scott G.. "Assessment of antimycobacterial activity of a series of mainly marine derived natural products". . p. 337 - 342. Retrieved 2007/10/03.
• 2、 Breton, Gary W.. "Selective Monoacetylation of Unsymmetrical Diols Catalyzed by Silica Gel-Supported Sodium Hydrogen Sulfate". . p. 8952 - 8954. Retrieved 2007/10/03.