THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]-

Base Information

• Chemical Name: THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]-
• CAS No.: 869725-77-9
• Molecular Formula: C₁₈H₂₅NOSSi
• Molecular Weight: 331.554
• Mol file: 869725-77-9.mol

Synonyms:THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]-

Chemical Property of THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]-

Chemical Property:

• Vapor Pressure: 2.69E-06mmHg at 25°C
• Boiling Point: 401.7°C at 760 mmHg
• Flash Point: 196.7°C
• PSA: 50.36000
• Density: 1.09g/cm³
• LogP: 5.81920

Purity/Quality:

2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]-

There total 1 articles about THIAZOLE, 2-[1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]-2,3-DIHYDRO-1H-INDEN-5-YL]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

[(5-bromo-2,3-dihydro-1H-inden-1-yl)oxy](tert-butyl)dimethylsilane (869725-76-8) → 2-(1-{[tert-butyl(dimethyl)silyl]oxy}-2,3-dihydro-1H-inden-5-yl)-1,3-thiazole (869725-77-9)

Guidance literature:

2-bromo-1,3-thiazole; With chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; for 0.25h;

[(5-bromo-2,3-dihydro-1H-inden-1-yl)oxy](tert-butyl)dimethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Heating / reflux;

Reference yield: 99.0%

2-(1-{[tert-butyl(dimethyl)silyl]oxy}-2,3-dihydro-1H-inden-5-yl)-1,3-thiazole (869725-77-9) → 5-(1,3-thiazol-2-yl)indan-1-ol (869725-78-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

[(5-bromo-2,3-dihydro-1H-inden-1-yl)oxy](tert-butyl)dimethylsilane

Downstream raw materials:

5-(1,3-thiazol-2-yl)indan-1-ol

Refernces