EQUILIN METHYL ETHER

Base Information

• Chemical Name: EQUILIN METHYL ETHER
• CAS No.: 6030-83-7
• Molecular Formula: C19H22O2
• Molecular Weight: 282.381
• Mol file: 6030-83-7.mol

Synonyms:equilin methyl ester;Estratetraenone Methyl Ether

Chemical Property of EQUILIN METHYL ETHER

Chemical Property:

• Melting Point: 161-163 °C
• Boiling Point: 439.1±45.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 4.04050

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of EQUILIN METHYL ETHER

There total 13 articles about EQUILIN METHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyestra-1,3,5(10),8(9)-tetraen-17β-ol (6733-79-5) → Equilin 3-methyl ether (6030-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: MCPBA, K₂CO₃ / benzene; hexane

2: H₂ / Pd-C / ethanol

3: POCl₃

4: NaOH / methanol

5: Ac₂O, DMSO

With sodium hydroxide; hydrogen; acetic anhydride; potassium carbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; hexane; benzene;

DOI:10.1016/S0040-4020(01)92768-1

Reference yield:

8α, 17β-dihydroxy-3-methoxy-oestra-1,3,5(10),9(11)-tetraen (13944-54-2) → Equilin 3-methyl ether (6030-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd-C / ethanol

2: POCl₃

3: NaOH / methanol

4: Ac₂O, DMSO

With sodium hydroxide; hydrogen; acetic anhydride; dimethyl sulfoxide; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1016/S0040-4020(01)92768-1

Reference yield:

(+/-)-8α-hydroxy-3-methoxyestra-1,3,5(10),9(11)-tetraen-17-one (21611-23-4,27833-51-8,33117-04-3) → 3-Methoxy-oestra-1,3,5(10),7-tetraen-17-on (rac-Equilin-methylaether) (6030-83-7,23962-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / ethanol

2: MeSO₂Cl, Py

With pyridine; hydrogen; methanesulfonyl chloride; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0040-4020(01)92768-1

upstream raw materials:

equilin

methyl p-toluene sulfonate

3-methoxy-1,3,5(10),7-estratetraen-17β-ol

3-methoxyestra-1,3,5(10),8(9)-tetraen-17β-ol

Downstream raw materials:

rac-3-Methoxy-oestra-1,3,5(10),7-tetraen-17β-ol

17β-dihydroequilin

d,l-equilin

rac-3-methoxy-(8α)-estra-1,3,5(10)-trien-17β-ol