SBE13 hydrochloride

Base Information

• Chemical Name: SBE13 hydrochloride
• CAS No.: 1052532-15-6
• Molecular Formula: C24H28Cl2N2O4
• Molecular Weight: 479.4
• European Community (EC) Number: 694-771-6
• ChEMBL ID: CHEMBL1584055
• DSSTox Substance ID: DTXSID10474576
• Mol file: 1052532-15-6.mol

Synonyms:1052532-15-6;SBE13 hydrochloride;SBE 13 hydrochloride;SBE 13 HCl;SBE13 (Hydrochloride);SBE-13 HCl;N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride;MLS000538104;N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;SBE13 HCl;CHEMBL1584055;SCHEMBL18797681;DTXSID10474576;EX-A814;BCP23836;CSB53215;s7720;AKOS024458077;CCG-269537;CS-3785;AC-35432;AS-57127;HY-15158;SMR000161652;SBE 13 hydrochloride, >=98% (HPLC);A935151;J-001365;({4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl}methyl)[2-(3,4-dimethoxyphenyl)ethyl]amine hydrochloride;N-({4-[(6-Chloropyridin-3-yl)methoxy]-3-methoxyphenyl}methyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine--hydrogen chloride (1/1);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine HCl;N-(4-((6-Chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethan-1-amine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methox y]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneeth anamine hydrochloride;hydrochloride;N-{4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxybenzyl}-2-(3,4-dimethoxyphenyl)ethanamine hydrochloride (1:1);N-{4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxybenzyl}-N-[2-(3,4-dimethoxyphenyl)ethyl]amine

Chemical Property of SBE13 hydrochloride

Chemical Property:

• PSA: 61.84000
• LogP: 5.86500
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥17mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 478.1426128
• Heavy Atom Count: 32
• Complexity: 500

Purity/Quality:

99.0% ^*data from raw suppliers

SBE13 Hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl
• Description: SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.
• Uses: SBE13 Hydrochloride is a selective inhibitor of PLK1.