3,4-Dichloro-5-fluorobromobenzene

Base Information

• Chemical Name: 3,4-Dichloro-5-fluorobromobenzene
• CAS No.: 1000572-93-9
• Molecular Formula: C6H2BrCl2F
• Molecular Weight: 243.89
• Hs Code.: 2903999090
• Mol file: 1000572-93-9.mol

Synonyms:3,4-Dichloro-5-fluorobromobenzene

Chemical Property of 3,4-Dichloro-5-fluorobromobenzene

Chemical Property:

• Boiling Point: 227.3±35.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.823±0.06 g/cm3(Predicted)
• LogP: 3.89500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3,4-Dichloro-5-fluorobromobenzene 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dichloro-5-fluorophenyl Bromide is used in preparation of arylmethylene heterocyclic compounds as Kv1.3 potassium shaker channel blockers.

Technology Process of 3,4-Dichloro-5-fluorobromobenzene

There total 2 articles about 3,4-Dichloro-5-fluorobromobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

4-bromo-2-chloro-6-fluorobenzeneamine (885453-49-6) → 5-bromo-1,2-dichloro-3-fluorobenzene (1000572-93-9)

Guidance literature:

With tert.-butylnitrite; copper dichloride; In acetonitrile; at 60 ℃; for 1.83333h;

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) → 5-bromo-1,2-dichloro-3-fluorobenzene (1000572-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-chloro-succinimide / acetonitrile / 2 h / Reflux

2: copper dichloride; tert.-butylnitrite / acetonitrile / 1.83 h / 60 °C

With N-chloro-succinimide; tert.-butylnitrite; copper dichloride; In acetonitrile;

Reference yield: 94.0%

5-bromo-1,2-dichloro-3-fluorobenzene (1000572-93-9) + Trimethyl borate (121-43-7,63156-11-6) → (3,4-dichloro-5-fluorophenyl)boronic acid (1023690-35-8)

Guidance literature:

5-bromo-1,2-dichloro-3-fluorobenzene; With TurboGrignard; In tetrahydrofuran; at -65 ℃; for 0.5h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at -65 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

4-bromo-2-chloro-6-fluorobenzeneamine

4-bromo-2-fluoroaniline

Downstream raw materials:

(3,4-dichloro-5-fluorophenyl)boronic acid

2-[(3,4-dichloro-5-fluoro-phenyl)-hydroxy-methyl]-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester

5-(5-(3,4-dichloro-5-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

2-(3,4-dichloro-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 -. "ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS". Page/Page column 72; 73. . Retrieved 2018/02/28.