UNC0379

Base Information

• Chemical Name: UNC0379
• CAS No.: 1620401-82-2
• Molecular Formula: C₂₃H₃₅N₅O₂
• Molecular Weight: 413.563
• Mol file: 1620401-82-2.mol

Synonyms:UNC0379;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine;6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine UNC0379;UNC0379, >=98%;UNC03;6,7-Dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine

Chemical Property of UNC0379

Chemical Property:

• Appearance/Colour: Off-white to light beige solid powder
• Boiling Point: 606.3±65.0 °C(Predicted)
• PKA: 10.54±0.20(Predicted)
• PSA: 62.75000
• Density: 1.168±0.06 g/cm3(Predicted)
• LogP: 4.00110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Soluble in DMSO (up to 30 mg/ml)

Purity/Quality:

99%+, ^*data from raw suppliers

UNC0379 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2

Technology Process of UNC0379

There total 1 articles about UNC0379 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) + 5-(pyrrolidin-1-yl)pentan-1-amine (71302-71-1) + 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) → 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine (1620401-82-2)

Guidance literature:

5-(pyrrolidin-1-yl)pentan-1-amine; 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

pyrrolidine; With N-ethyl-N,N-diisopropylamine; In butan-1-ol; Microwave irradiation; Heating;

DOI:10.1039/c4md00317a

upstream raw materials:

pyrrolidine

5-(pyrrolidin-1-yl)pentan-1-amine

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

Refernces