2,4-dichloro-6-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 2,4-dichloro-6-(trifluoromethyl)pyrimidine
• CAS No.: 16097-64-6
• Molecular Formula: C5H Cl2 F3 N2
• Molecular Weight: 216.978
• Hs Code.: 29335990
• Mol file: 16097-64-6.mol

Synonyms:2,4-Dichloro-6-trifluoromethylpyrimidine;NSC 338593

Chemical Property of 2,4-dichloro-6-(trifluoromethyl)pyrimidine

Chemical Property:

• Vapor Pressure: 0.334mmHg at 25°C
• Melting Point: -48--46 °C
• Refractive Index: 1.4640
• Boiling Point: 206.9°Cat760mmHg
• PKA: -7.56±0.32(Predicted)
• Flash Point: 78.9°C
• PSA: 25.78000
• Density: 1.627g/cm³
• LogP: 2.80220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-6-trifluoromethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichloro-6-trifluoromethylpyrimidine is a useful synthetic intermediate. It can be used to synthesize 2,4-diaminopyrimidines derivatives that show antiplasmodial activities.

Technology Process of 2,4-dichloro-6-(trifluoromethyl)pyrimidine

There total 16 articles about 2,4-dichloro-6-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-trifluoromethyluracil (672-45-7) → 2,4-dichloro-6-(trifluoromethyl)-pyrimidine (16097-64-6)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; for 6h; Heating / reflux;

Reference yield: 83.0%

6-Trifluoromethyluracil (672-45-7) → 2,4-dichloro-6-(trifluoromethyl)-pyrimidine (16097-64-6)

Guidance literature:

With tri-n-propylamine; trichlorophosphate; for 3h; Heating;

Reference yield: 83.0%

4-Amino-6-trifluoromethylpyrimidin-2-ol Hydrochloride (85730-37-6) → 2,4-dichloro-6-(trifluoromethyl)-pyrimidine (16097-64-6)

Guidance literature:

With trichlorophosphate; N,N-diethylaniline; for 3h; Heating;

DOI:10.1002/jhet.5570200145

upstream raw materials:

tri-n-propylamine

6-Trifluoromethyluracil

tributyl-amine

4-Chloro-6-trifluoromethylpyrimidin-2-yldichlorophosphate

Downstream raw materials:

[(1R,5S,6R)-3-{2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid

2-chloro-4-phenyl-6-(trifluoromethyl)pyrimidine

Refernces

• 1、 -. "Spirocyclic derivatives". Page/Page column 114; 115. . Retrieved 2016/04/09.
• 2、 -. "METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF". Paragraph 00398. . Retrieved 2016/01/01.