1,3-benzenediethanol

Base Information

• Chemical Name: 1,3-benzenediethanol
• CAS No.: 46133-05-5
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol file: 46133-05-5.mol

Synonyms:1,3-benzenediethanol

Chemical Property of 1,3-benzenediethanol

Chemical Property:

• Boiling Point: 182 °C (1 mmHg)
• PSA: 40.46000
• LogP: 0.75620

Purity/Quality:

95+% ^*data from raw suppliers

2,2''-(1,3-Phenylene)diethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2''-(1,3-Phenylene)diethanol is a useful reactant in organic synthesis.

Technology Process of 1,3-benzenediethanol

There total 7 articles about 1,3-benzenediethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,3-benzenediacetic acid (19806-17-8) → 1,3-Bis(2'-hydroxyethyl)benzene (46133-05-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jo00003a050

Reference yield: 1.6%

2,6-dimethylpyridine (108-48-5) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2-(6-methylpyridin-2-yl)-ethanol (934-78-1) + 2-(6-methylpyridin-2-yl)propane-1,3-diol (1076-58-0) + 1,3-Bis(2'-hydroxyethyl)benzene (46133-05-5)

Guidance literature:

In water; at 135 ℃; for 12h; High pressure;

DOI:10.1039/c5cc09445c

Reference yield:

diethyl 2,2'-(1,3-phenylene)diacetate (36076-20-7) → 1,3-Bis(2'-hydroxyethyl)benzene (46133-05-5)

Guidance literature:

With ethanol; sodium;

DOI:10.1002/hlca.193201501138

upstream raw materials:

diethyl 2,2'-(1,3-phenylene)diacetate

1,3-bis-(2-acetoxy-ethyl)-benzene

1,3-benzenediacetic acid

1,3-Bis(2-aminoethyl)benzol

Downstream raw materials:

3-(3-(3-hydroxypropyl)phenyl)propanol

1,3-Bis<2-cyanoethyl>benzene

3,3'-(1,3-phenylene)bis(ethyl propionate)

4-chloro-N-(3-(2-(2-hydroxy-5-oxocyclopent-1-en-1-yl)ethyl)phenethyl)benzenesulfonamide

Refernces

• 1、 -. "Cycloalkyl-dione Derivatives And Methods Of Their Use". Page/Page column 23. . Retrieved 2013/02/28.
• 2、 Ballatore, Carlo,Soper, James H.,Piscitelli, Francesco,James, Michael,Huang, Longchuan,Atasoylu, Onur,Huryn, Donna M.,Trojanowski, John Q.,Lee, Virginia M.-Y.,Brunden, Kurt R.,Smith, Amos B.. "Cyclopentane-1,3-dione: A novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists". experimental part. p. 6969 - 6983. Retrieved 2011/12/02.